Bioavailability of prednisolone tablets
dc.contributor.author | Weidler, Donald J. | en_US |
dc.contributor.author | Bachmaan, Hannelore G. | en_US |
dc.contributor.author | Hallmark, Margarette R. | en_US |
dc.contributor.author | Sakmar, Ermelinda | en_US |
dc.contributor.author | Tembo, Aubrey V. | en_US |
dc.contributor.author | Wagner, John G. | en_US |
dc.date.accessioned | 2006-09-11T15:38:22Z | |
dc.date.available | 2006-09-11T15:38:22Z | |
dc.date.issued | 1977-05 | en_US |
dc.identifier.citation | Tembo, Aubrey V.; Hallmark, Margarette R.; Sakmar, Ermelinda; Bachmaan, Hannelore G.; Weidler, Donald J.; Wagner, John G.; (1977). "Bioavailability of prednisolone tablets." Journal of Pharmacokinetics and Biopharmaceutics 5(3): 257-270. <http://hdl.handle.net/2027.42/45072> | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45072 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=577932&dopt=citation | en_US |
dc.description.abstract | Two fourtreatment crossover studies were performed using 12 adult male volunteers in each with seven different commercially available prednisolone tablets. Plasma samples were assayed for prednisolone by a radioimmunoassay method. Statisacal analyses of the data, by analysis of variance for crossover design (ANOVA), showed no significant differences among the treatment averages at any of the sampling times except at 0.25 and 4 hr in one of the studies. There were also no significant differences among the treatment averages for peak plasma level, time of peak plasma level, area 0–12 hr, area 0–24 hr, and the halflife of elimination of prednisolone. We conclude that the average plasma concentrations of prednisolone are superimposable in a statistical sense and that the tablets tested are bioequivalent. Results of dissolution studies of six tablets of each of the seven lots of prednisolone tablets, using deaerated water in the spin filter apparatus, are presented. | en_US |
dc.format.extent | 940896 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corp. ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Elimination Half-life of Prednisoione | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Prednisolone Bioavailability | en_US |
dc.subject.other | Prednisolone Radioimmunoassay | en_US |
dc.subject.other | Prednisolone Plasma Concentrations | en_US |
dc.subject.other | In Vitro Rate of Dissolution of Prednisolone from Tablets | en_US |
dc.title | Bioavailability of prednisolone tablets | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48109, Ann Arbor, Michigan; Ministry of Health, Lilongwe, Malawi | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy and Upjohn Center for Clinical Pharmacology, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 577932 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45072/1/10928_2005_Article_BF01065399.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01065399 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Biopharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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