Novel method of estimating volume of distribution of a drug obeying Michaelis-Menten elimination kinetics
dc.contributor.author | Garg, Dyal C. | en_US |
dc.contributor.author | Wagner, John G. | en_US |
dc.contributor.author | Weidler, Donald J. | en_US |
dc.contributor.author | Lin, Yi-Jong | en_US |
dc.date.accessioned | 2006-09-11T15:38:31Z | |
dc.date.available | 2006-09-11T15:38:31Z | |
dc.date.issued | 1978-06 | en_US |
dc.identifier.citation | Lin, Yi-Jong; Weidler, Donald J.; Garg, Dyal C.; Wagner, John G.; (1978). "Novel method of estimating volume of distribution of a drug obeying Michaelis-Menten elimination kinetics." Journal of Pharmacokinetics and Biopharmaceutics 6(3): 197-207. <http://hdl.handle.net/2027.42/45074> | en_US |
dc.identifier.issn | 1573-8744 | en_US |
dc.identifier.issn | 0090-466X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45074 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=671226&dopt=citation | en_US |
dc.description.abstract | The novel method of estimating the volume of distribution involves (a) administering an appropriate bolus intravenous dose of the drug, (b) starting a constant-rate intravenous infusion of the drug at the same time, (c) maintaining the infusion for a given number of hours, (a) measuring the drug concentration over the entire time course, (e) computer-fitting the post-infusion data to obtain estimates of V m and K m , (f) estimating the total area under the concentration-time curve from zero time to infinity, and (g) iteratively solving a cubic equation to obtain the estimate of the volume of distribution. The method was applied to ethanol in the cat and yielded an average value of 635ml/kg (63.5% of body weight) with a coefficient of variation of 23.0%. This is equivalent to total body water in the cat. | en_US |
dc.format.extent | 484483 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Volume of Distribution | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Veterinary Medicine | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Ethanol | en_US |
dc.subject.other | Michaelis-Menten Elimination Kinetics | en_US |
dc.title | Novel method of estimating volume of distribution of a drug obeying Michaelis-Menten elimination kinetics | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109, Ann Arbor, Michigan; School of Pharmacy, University of Missouri, 64110, Kansas City, Missouri | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, School of Medicine, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, 48109, Ann Arbor, Michigan; Upjohn Center for Clinical Pharmacology, The University of Michigan Medical Center, 48109, Ann Arbor, MI | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 671226 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45074/1/10928_2005_Article_BF01312262.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01312262 | en_US |
dc.identifier.source | Journal of Pharmacokinetics and Biopharmaceutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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