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The cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivo
dc.contributor.authorWheeler, Richard H.en_US
dc.contributor.authorClauw, Daniel J.en_US
dc.contributor.authorNatale, Ronald B.en_US
dc.contributor.authorRuddon, Raymond W.en_US
dc.date.accessioned2006-09-11T15:42:44Z
dc.date.available2006-09-11T15:42:44Z
dc.date.issued1983-12en_US
dc.identifier.citationWheeler, Richard H.; Clauw, Daniel J.; Natale, Ronald B.; Ruddon, Raymond W.; (1983). "The cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivo ." Investigational New Drugs 1(4): 283-295. <http://hdl.handle.net/2027.42/45135>en_US
dc.identifier.issn0167-6997en_US
dc.identifier.issn1573-0646en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/45135
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6432722&dopt=citationen_US
dc.description.abstractThe cytotoxic and cytokinetic effects of ICRF-159 and its d-enantiomer ICRF-187 have been examined in vitro . The effects of both agents were identical. Cytotoxicity is dependent on both the drug concentration and the duration of drug exposure. Drug exposure for twice the cell cycle time is necessary for maximum effect. Cytotoxicity is also dependent upon the rate of cell proliferation. A rapidly growing cell population is more sensitive to brief drug exposure than a slowly growing population.en_US
dc.format.extent916074 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers; Martinus Nijhoff Publishers ; Springer Science+Business Mediaen_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherOncologyen_US
dc.subject.otherCytokinetic Effectsen_US
dc.subject.otherCytotoxicityen_US
dc.subject.otherICRF-159/187en_US
dc.titleThe cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivoen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelRadiologyen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA; Comprehensive Cancer Center, University of Alabama in Birmingham, University Station, 35294, Birmingham, AL, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA; Veterans Administration Medical Center, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid6432722en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/45135/1/10637_2004_Article_BF00177411.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00177411en_US
dc.identifier.sourceInvestigational New Drugsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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