Endogenous regulation of the acute inflammatory response
dc.contributor.author | Lentsch, Alex B. | en_US |
dc.contributor.author | Ward, Peter A. | en_US |
dc.date.accessioned | 2006-09-11T15:56:42Z | |
dc.date.available | 2006-09-11T15:56:42Z | |
dc.date.issued | 2002-05 | en_US |
dc.identifier.citation | Ward, Peter A.; Lentsch, Alex B.; (2002). "Endogenous regulation of the acute inflammatory response." Molecular and Cellular Biochemistry 234-235(1): 225-228. <http://hdl.handle.net/2027.42/45338> | en_US |
dc.identifier.issn | 0300-8177 | en_US |
dc.identifier.issn | 1573-4919 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45338 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12162438&dopt=citation | en_US |
dc.description.abstract | The acute inflammatory response has been triggered in rat lungs by deposition of IgG immune complexes. The inflammatory reaction triggered is highly tissue damaging and requires activation of NF-κB with ensuing generation of chemokines and cytokines. Endogenous generation of IL-10 and IL-13 as well as secretory leukocyte protease inhibitor (SLPI), significantly regulates this inflammatory response. IL-10 and IL-13 attenuate NF-κB activation by interfering with breakdown of IκBα, while SLPI likewise suppresses NF-κB activation, but by interfering with breakdown of IκBβ. Antibody induced blockade of IL-10, IL-13 or SLPI enhances NF-κB activation in lung and exacerbates the lung inflammatory response and injury. These data indicate that endogenous IL-10, IL-13 and SLPI are important regulators of the inflammatory response by reducing gene activation with resultant generation of peptide mediators/cytokines and chemokines. | en_US |
dc.format.extent | 151790 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Medical Biochemistry | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Inflammation | en_US |
dc.subject.other | Neutrophils | en_US |
dc.subject.other | Lung Injury | en_US |
dc.subject.other | NF-κB | en_US |
dc.subject.other | Cardiology | en_US |
dc.title | Endogenous regulation of the acute inflammatory response | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12162438 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45338/1/11010_2004_Article_407649.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015944709177 | en_US |
dc.identifier.source | Molecular and Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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