Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture
dc.contributor.author | Macdonald, Robert L. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.date.accessioned | 2006-09-11T15:57:10Z | |
dc.date.available | 2006-09-11T15:57:10Z | |
dc.date.issued | 1981-01 | en_US |
dc.identifier.citation | Macdonald, Robert L.; Young, Anne B.; (1981). "Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture." Molecular and Cellular Biochemistry 38(1): 147-162. <http://hdl.handle.net/2027.42/45345> | en_US |
dc.identifier.issn | 0300-8177 | en_US |
dc.identifier.issn | 1573-4919 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45345 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6270545&dopt=citation | en_US |
dc.description.abstract | In this paper it is shown that the postsynaptic GABA-receptor chloride ion channel complex is composed of several functional subunits. There are probably at least two stereospecific locations on the receptor for GABA-binding and both must be occupied to obtain an increase in chloride conductance. The interaction between these sites is uncertain but there could be either positive cooperativity between the sites or only a requirement that both sites are occupied without occupation of either site affecting the affinity for GABA of the other site. There is a chloride conductance channel coupled to the GABA receptor which opens for an average of 20 msec and has an average conductance of 18 pS. The GABA-coupled chloride channel may or may not have the same composition as the glycine coupled chloride channel. | en_US |
dc.format.extent | 1430421 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Martinus Nijhoff/Dr. W. Junk Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Medical Biochemistry | en_US |
dc.subject.other | Oncology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Cardiology | en_US |
dc.title | Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Dept. of Neurology, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Dept. of Neurology, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6270545 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45345/1/11010_2004_Article_BF00235693.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00235693 | en_US |
dc.identifier.source | Molecular and Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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