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Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture

dc.contributor.authorMacdonald, Robert L.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.date.accessioned2006-09-11T15:57:10Z
dc.date.available2006-09-11T15:57:10Z
dc.date.issued1981-01en_US
dc.identifier.citationMacdonald, Robert L.; Young, Anne B.; (1981). "Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture." Molecular and Cellular Biochemistry 38(1): 147-162. <http://hdl.handle.net/2027.42/45345>en_US
dc.identifier.issn0300-8177en_US
dc.identifier.issn1573-4919en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/45345
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6270545&dopt=citationen_US
dc.description.abstractIn this paper it is shown that the postsynaptic GABA-receptor chloride ion channel complex is composed of several functional subunits. There are probably at least two stereospecific locations on the receptor for GABA-binding and both must be occupied to obtain an increase in chloride conductance. The interaction between these sites is uncertain but there could be either positive cooperativity between the sites or only a requirement that both sites are occupied without occupation of either site affecting the affinity for GABA of the other site. There is a chloride conductance channel coupled to the GABA receptor which opens for an average of 20 msec and has an average conductance of 18 pS. The GABA-coupled chloride channel may or may not have the same composition as the glycine coupled chloride channel.en_US
dc.format.extent1430421 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherMartinus Nijhoff/Dr. W. Junk Publishers; Springer Science+Business Mediaen_US
dc.subject.otherLife Sciencesen_US
dc.subject.otherMedical Biochemistryen_US
dc.subject.otherOncologyen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherCardiologyen_US
dc.titlePharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell cultureen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDept. of Neurology, University of Michigan, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDept. of Neurology, University of Michigan, 48109, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid6270545en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/45345/1/11010_2004_Article_BF00235693.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00235693en_US
dc.identifier.sourceMolecular and Cellular Biochemistryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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