Imaging Changes after Stereotactic Radiosurgery of Primary and Secondary Malignant Brain Tumors
dc.contributor.author | Balter, James M. | en_US |
dc.contributor.author | Hayman, James A. | en_US |
dc.contributor.author | Archer, Paul G. | en_US |
dc.contributor.author | Auer, Donna L. | en_US |
dc.contributor.author | Sandler, Howard M. | en_US |
dc.contributor.author | Ross, Donald A. | en_US |
dc.date.accessioned | 2006-09-11T16:00:21Z | |
dc.date.available | 2006-09-11T16:00:21Z | |
dc.date.issued | 2002-01 | en_US |
dc.identifier.citation | Ross, Donald A.; Sandler, Howard M.; Balter, James M.; Hayman, James A.; Archer, Paul G.; Auer, Donna L.; (2002). "Imaging Changes after Stereotactic Radiosurgery of Primary and Secondary Malignant Brain Tumors." Journal of Neuro-Oncology 56(2): 175-181. <http://hdl.handle.net/2027.42/45392> | en_US |
dc.identifier.issn | 0167-594X | en_US |
dc.identifier.issn | 1573-7373 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45392 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11995819&dopt=citation | en_US |
dc.description.abstract | After radiosurgery of malignant tumors, it can be difficult to discriminate between transient treatment effects, radiation necrosis, and tumor progression on post-treatment imaging. Misinterpretation of an enlarging lesion may lead to inappropriate treatment and contribute to disagreements about treatment efficacy. In an effort to clarify this problem, we reviewed our experience with interpreting post-radiosurgical imaging in patients with malignant primary and secondary brain tumors. We reviewed results of radiosurgery of 30 malignant gliomas and 35 metastatic brain tumors with minimum follow up of 1 year or until death. Of 30 gliomas, 73% were larger a mean of 13 weeks after radiosurgery. Of 35 metatstatic tumors, 22% were larger a mean of 10 weeks after radiosurgery. Eleven had 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) of enlarging lesions. Eight showed increased activity with respect to brain; three decreased activity. Of the eight, six predicted incorrectly based upon the patients' subsequent courses (all alive, mean follow up of 27 months), and two correctly, with the patients dying from the imaged lesions 8 and 13 months later. Of the three with FDG uptake less than brain, one patient was alive with 32 weeks of follow up, and two patients died from the imaged lesion 13 and 21 months later. Radiographic enlargement after radiosurgery is common, especially for gliomas. Physicians caring for these patients should be aware of this phenomenon and be cautious in interpreting post-treatment images. MRI appearance may be useful for metastases. FDG-PET seems unreliable. Further evaluation of Tl-201 and HMPAO SPECT or MRS is warranted. | en_US |
dc.format.extent | 581471 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers; Springer Science+Business Media | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Glioma | en_US |
dc.subject.other | Magnetic Resonance Imaging | en_US |
dc.subject.other | Metastasis to Brain | en_US |
dc.subject.other | Single Photon Emission Computed Tomography | en_US |
dc.subject.other | Stereotactic Radiosurgery | en_US |
dc.subject.other | Positron Emission Tomography | en_US |
dc.subject.other | Oncology | en_US |
dc.title | Imaging Changes after Stereotactic Radiosurgery of Primary and Secondary Malignant Brain Tumors | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Ophthalmology | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Obstetrics and Gynecology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, Medford, OR, USA; Section of Neurosurgery, Department of Radiation Oncology, University of Michigan, Medford, OR, USA | en_US |
dc.contributor.affiliationum | Section of Neurosurgery, Department of Radiation Oncology, University of Michigan, Medford, OR, USA | en_US |
dc.contributor.affiliationum | Section of Neurosurgery, Department of Radiation Oncology, University of Michigan, Medford, OR, USA | en_US |
dc.contributor.affiliationum | Section of Neurosurgery, Department of Radiation Oncology, University of Michigan, Medford, OR, USA | en_US |
dc.contributor.affiliationum | Section of Neurosurgery, Department of Radiation Oncology, University of Michigan, Medford, OR, USA | en_US |
dc.contributor.affiliationother | Department of Surgery, Medford, OR, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11995819 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45392/1/11060_2004_Article_393674.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1014571900854 | en_US |
dc.identifier.source | Journal of Neuro-Oncology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.