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The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat
dc.contributor.authorSchatz, Robert A.en_US
dc.contributor.authorSellinger, Otto Z.en_US
dc.contributor.authorHarris, Ronalden_US
dc.date.accessioned2006-09-11T16:00:47Z
dc.date.available2006-09-11T16:00:47Z
dc.date.issued1976-02en_US
dc.identifier.citationSchatz, Robert A.; Harris, Ronald; Sellinger, Otto Z.; (1976). "The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat." Neurochemical Research 1(1): 53-63. <http://hdl.handle.net/2027.42/45398>en_US
dc.identifier.issn0364-3190en_US
dc.identifier.issn1573-6903en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/45398
dc.description.abstractThe effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine (MSO) in 7 rat brain regions, the spinal cord, the liver, and the kidney was investigated. The administration of methionine decreased the uptake of MSO in all brain regions. The uptake of MSO by and its distribution in the nervous tissue was uniform and failed to result in any preferential accumulation of the drug. Methionine decreased the amount of MSO bound to cerebral structures and to the spinal cord. MSO bound to the spinal cord was less susceptible to release by Triton X-100 than was brain-bound MSO.en_US
dc.format.extent514811 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherNeurologyen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherNeurosciencesen_US
dc.titleThe effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the raten_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48014, Ann Arbor, Michiganen_US
dc.contributor.affiliationumLaboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48014, Ann Arbor, Michiganen_US
dc.contributor.affiliationumLaboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48014, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid24271244en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/45398/1/11064_2004_Article_BF00965631.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00965631en_US
dc.identifier.sourceNeurochemical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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