Autoradiographic quantification of muscarinic cholinergic synaptic markers in bat, shrew, and rat brain
dc.contributor.author | Albin, Roger L. | en_US |
dc.contributor.author | Howland, Morgan M. | en_US |
dc.contributor.author | Frey, Kirk A. | en_US |
dc.contributor.author | Higgins, Donald S. | en_US |
dc.date.accessioned | 2006-09-11T16:01:35Z | |
dc.date.available | 2006-09-11T16:01:35Z | |
dc.date.issued | 1994-05 | en_US |
dc.identifier.citation | Albin, Roger L.; Howland, Morgan M.; Higgins, Donald S.; Frey, Kirk A.; (1994). "Autoradiographic quantification of muscarinic cholinergic synaptic markers in bat, shrew, and rat brain." Neurochemical Research 19(5): 581-589. <http://hdl.handle.net/2027.42/45409> | en_US |
dc.identifier.issn | 0364-3190 | en_US |
dc.identifier.issn | 1573-6903 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45409 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8065514&dopt=citation | en_US |
dc.description.abstract | We employed radioligand binding autoradiography to determine the distributions of pre- and postsynaptic cholinergic radioligand binding sites in the brains of two species of bat, one species of shrew, and the rat. High affinity choline uptake sites were measured with [ 3 H]hemicholinium, and presynaptic cholinergic vesicles were identified with [ 3 H]vesamicol. Muscarinic cholinergic receptors were determined with [ 3 H]scopolamine. The distribution patterns of the three cholinergic markers were similar in all species examined, and identified known major cholinergic pathways on the basis of enrichments in both pre- and postsynaptic markers. In addition, there was excellent agreement, both within and across species, in the regional distributions of the two presynaptic cholinergic markers. Our results indicate that pharmacological identifiers of cholinergic pathways and synapses, including the cholinergic vesicle transport site, and the organizations of central nervous system cholinergic pathways are phylogenetically conserved among eutherian mammals. | en_US |
dc.format.extent | 2571124 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Cholinergic Vesicle | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Hemicholinium-3 | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Vesamicol | en_US |
dc.subject.other | Scopolamine | en_US |
dc.subject.other | Muscarinic Receptor | en_US |
dc.subject.other | High-affinity Choline Uptake | en_US |
dc.title | Autoradiographic quantification of muscarinic cholinergic synaptic markers in bat, shrew, and rat brain | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Dept. of Neurology Hospitals, The University of Michigan, Ann Arbor, MI; Neuroscience Program, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Dept. of Neurology Hospitals, The University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Dept. of Neurology Hospitals, The University of Michigan, Ann Arbor, MI; Neuroscience Program, The University of Michigan, Ann Arbor, MI; Mental Health Research Institute, The University of Michigan, Ann Arbor, MI; Division of Nuclear Medicine, The University of Michigan, 1500 E. Medical Center Dr., B1G 412-0028 AGH, 48109-0028, Ann Arbor, MI; The University of Michigan Hospitals, 1500 E. Medical Center Dr., B1G 412-0028 AGH, 48109-0028, Ann Arbor, MI | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8065514 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45409/1/11064_2004_Article_BF00971334.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00971334 | en_US |
dc.identifier.source | Neurochemical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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