S -Adenosyl- l -homocysteine in brain
dc.contributor.author | Vunnam, Chouda Rani | en_US |
dc.contributor.author | Sellinger, Otto Z. | en_US |
dc.contributor.author | Schatz, Robert A. | en_US |
dc.date.accessioned | 2006-09-11T16:01:45Z | |
dc.date.available | 2006-09-11T16:01:45Z | |
dc.date.issued | 1977-02 | en_US |
dc.identifier.citation | Schatz, Robert A.; Vunnam, Chouda Rani; Sellinger, Otto Z.; (1977). " S -Adenosyl- l -homocysteine in brain." Neurochemical Research 2(1): 27-38. <http://hdl.handle.net/2027.42/45411> | en_US |
dc.identifier.issn | 0364-3190 | en_US |
dc.identifier.issn | 1573-6903 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45411 | |
dc.description.abstract | Administration of methionine sulfoximine (MSO) to rats and mice significantly decreased cerebral levels of S -adenosyl- l -homocysteine (AdoHcy). Concurrent administration of methionine prevented this decrease and, when methionine was given alone, significantly elevated AdoHcy levels resulted in both species. Regionally, AdoHcy levels varied from 20 nmol/g in rat cerebellum and spinal cord to about 60 nmol/g in hypothalamus and midbrain. MSO decreased AdoHcy in all regions tested except striatum, midbrain, and spinal cord. AdoMet/AdoHcy ratios (methylation index) varied from 0.48 in hypothalamus to 2.4 in cerebellum, and MSO administration decreased these ratios in all regions except hypothalamus. AdoHcy hydrolase activity was lowest in hypothalamus, highest in brainstem and, generally, varied inversely with regional AdoHcy levels. MSO decreased AdoHcy hydrolase activity in all regions except hypothalamus and spinal cord. Cycloleucine administration resulted in significantly decreased levels of mouse brain AdoHcy, whereas the administration of dihydroxyphenylalanine (DOPA) failed to affect AdoHcy levels. It is concluded that (a) cerebral AdoHcy levels are more tightly regulated than are those of AdoMet after MSO administration, (b) slight fluctuations of AdoHcy levels may be important in regulating AdoHcy hydrolase activity and hence AdoHcy catabolism in vivo, (c) the AdoMet/AdoHcy ratio reflects the absolute AdoMet concentration rather than the transmethylation flux, (d) the decreased AdoMet levels in midbrain, cortex, and striatum after MSO with no corresponding decrease in AdoHcy suggest an enhanced AdoMet utilization, hence an increased transmethylation in the MSO preconvulsant state. | en_US |
dc.format.extent | 661019 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.title | S -Adenosyl- l -homocysteine in brain | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 24271847 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45411/1/11064_2004_Article_BF00966019.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00966019 | en_US |
dc.identifier.source | Neurochemical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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