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Isolation and Immunocytochemical Characterization of Three Tachykinin-Related Peptides from the Mosquito, Culex salinarius

dc.contributor.authorPendleton, Michael W.en_US
dc.contributor.authorOlson, Jimmy K.en_US
dc.contributor.authorClottens, Frank L.en_US
dc.contributor.authorNachman, Ronald J.en_US
dc.contributor.authorHolman, G. Marken_US
dc.contributor.authorMeola, Shirlee M.en_US
dc.contributor.authorWright, Mark S.en_US
dc.contributor.authorHayes, Timothy K.en_US
dc.contributor.authorSchoofs, Lilianeen_US
dc.contributor.authorNichols, Ruthannen_US
dc.date.accessioned2006-09-11T16:02:10Z
dc.date.available2006-09-11T16:02:10Z
dc.date.issued1998-02en_US
dc.identifier.citationMeola, Shirlee M.; Clottens, Frank L.; Holman, G. Mark; Nachman, Ronald J.; Nichols, Ruthann; Schoofs, Liliane; Wright, Mark S.; Olson, Jimmy K.; Hayes, Timothy K.; Pendleton, Michael W.; (1998). "Isolation and Immunocytochemical Characterization of Three Tachykinin-Related Peptides from the Mosquito, Culex salinarius ." Neurochemical Research 23(2): 189-202. <http://hdl.handle.net/2027.42/45417>en_US
dc.identifier.issn0364-3190en_US
dc.identifier.issn1573-6903en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/45417
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9475514&dopt=citationen_US
dc.description.abstractThree myotropic peptides belonging to the Arg-amide insect tachykinin family were isolated from whole-body extracts of the mosquito, Culex salinarius . The peptides, APSGFMGMR-NH 2 , APYGFTGMR-NH 2 and APSGFFGMR-NH 2 (designated culetachykinin I, II, and III) were isolated and purified on the basis of their ability to stimulate muscle contractions of isolated Leucophaea maderae hindgut. Biologically inactive methionine sulfoxides of two of the three peptides were isolated using an ELISA system based upon antiserum raised against APYGFTGMR-NH 2 and identified with mass spectrometry. Immunocytochemistry localized these peptides in cells in the brain, antennae, subesophageal, thoracic and abdominal ganglion, proventriculus and midgut. Nerve tracts containing these peptides were found in the median nerve of the brain, central body, nervi corpus cardiaci, cervical nerve, antennal lobe and on the surface of the midgut.en_US
dc.format.extent4992360 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPeptide Identificationen_US
dc.subject.otherNeuromodulatorsen_US
dc.subject.otherMyotropinsen_US
dc.subject.otherNeurosciencesen_US
dc.subject.otherNeurologyen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherInsect Tachykininsen_US
dc.subject.otherHomologyen_US
dc.titleIsolation and Immunocytochemical Characterization of Three Tachykinin-Related Peptides from the Mosquito, Culex salinariusen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry and Biology, University of Michigan, Ann Arbor, MI, 48109-1048en_US
dc.contributor.affiliationotherFood Animal Protection Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 2881 F & B Road, College Station, TX, 77845en_US
dc.contributor.affiliationotherFood Animal Protection Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 2881 F & B Road, College Station, TX, 77845en_US
dc.contributor.affiliationotherFood Animal Protection Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 2881 F & B Road, College Station, TX, 77845en_US
dc.contributor.affiliationotherFood Animal Protection Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 2881 F & B Road, College Station, TX, 77845en_US
dc.contributor.affiliationotherZoological Institute, Catholic University of Leuven, Naamsestraat 59, B-3000, Leuven, (Belgium)en_US
dc.contributor.affiliationotherDepartment of Entomology, Institute for Biosciences and Technology, Texas A & M University, College Station, TX, 77843en_US
dc.contributor.affiliationotherDepartment of Entomology, Texas Agricultural Experiment Station, Texas A & M University, College Station, TX, 77843en_US
dc.contributor.affiliationotherDepartment of Entomology, Institute for Biosciences and Technology, Texas A & M University, College Station, TX, 77843en_US
dc.contributor.affiliationotherFood Animal Protection Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, 2881 F & B Road, College Station, TX, 77845en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid9475514en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/45417/1/11064_2004_Article_419298.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1022432909360en_US
dc.identifier.sourceNeurochemical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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