Anticonvulsant activity of cyclopentano amino acids
dc.contributor.author | Zand, Robert | en_US |
dc.contributor.author | Izquierdo, Iván | en_US |
dc.date.accessioned | 2006-09-11T16:02:48Z | |
dc.date.available | 2006-09-11T16:02:48Z | |
dc.date.issued | 1980-01 | en_US |
dc.identifier.citation | Zand, Robert; Izquierdo, Ivan; (1980). "Anticonvulsant activity of cyclopentano amino acids." Neurochemical Research 5(1): 1-7. <http://hdl.handle.net/2027.42/45426> | en_US |
dc.identifier.issn | 0364-3190 | en_US |
dc.identifier.issn | 1573-6903 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45426 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7366792&dopt=citation | en_US |
dc.description.abstract | The hypothesis that certain amino acid analogues possessing a five-membered ring structure or amino acid analogues that can be viewed as fragments derived from such a ring would have anticonvulsant activity was proposed and tested. The compounds 1-aminocyclopentane carboxylic acid, 1-amino-3-methylcyclopentane carboxylic acid, 3-aminotetrahydrothiophene carboxylic acid, and α-aminoisobutyric acid were found to protect rats against seizures in the maximal electroshock test but offered no protection against metrazol-(pentylenetetrazol) induced seizures in mice. The structural feature of this class of anticonvulsants that allows for hydrophobic interactions at the receptor site is considered to be a major physical factor necessary in promoting the activity of this class of anticonvulsants. | en_US |
dc.format.extent | 373559 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Neurosciences | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.title | Anticonvulsant activity of cyclopentano amino acids | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Biophysics Research Division, Institute of Science and Technology and Department of Biological Chemistry, The University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Biological Chemistry, Institute Biociences Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7366792 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45426/1/11064_2004_Article_BF00964455.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00964455 | en_US |
dc.identifier.source | Neurochemical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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