Effect of methionine sulfoximine on methylation of guanine residues in astroglial transfer ribonucleic acids
dc.contributor.author | Sellinger, Otto Z. | en_US |
dc.contributor.author | Der, Orchid | en_US |
dc.date.accessioned | 2006-09-11T16:02:53Z | |
dc.date.available | 2006-09-11T16:02:53Z | |
dc.date.issued | 1981-02 | en_US |
dc.identifier.citation | Sellinger, Otto Z.; Der, Orchid; (1981). "Effect of methionine sulfoximine on methylation of guanine residues in astroglial transfer ribonucleic acids." Neurochemical Research 6(2): 153-162. <http://hdl.handle.net/2027.42/45427> | en_US |
dc.identifier.issn | 0364-3190 | en_US |
dc.identifier.issn | 1573-6903 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45427 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7242776&dopt=citation | en_US |
dc.description.abstract | Culture-grown astrocytes derived from 3-day-old rat brain were incubated in the presence of [ 3 H]guanosine and of the convulsant agent l -methionine- dl -sulfoximine (MSO). The resulting [ 3 H]tRNA was purified from control and MSO-exposed cells at several time points during the incubation and was hydrolyzed to [ 3 H]guanine and four [ 3 H]methyl guanines which were separated by high pressure liquid chromatography. Three of the four [ 3 H]methyl guanines were more highly labeled in the [ 3 H]tRNA of the MSO-exposed cells, relative to that of the control cells throughout the entire incubation period. The findings extend to cultured astrocytes, the stimulatory effect of MSO on the methylation of neural tRNA guanines, previouly observed both in vitro using [ 14 C] S -adenosyl- l -methionine and in vivo using [ methyl 3 -H] l -methionine. | en_US |
dc.format.extent | 473999 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Neurosciences | en_US |
dc.title | Effect of methionine sulfoximine on methylation of guanine residues in astroglial transfer ribonucleic acids | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Laboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48109, Ann Arbor, Michigan; Department of Pharmacology, The University of Wisconsin Center for Health Sciences, 53706, Madison, Wisconsin | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7242776 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45427/1/11064_2004_Article_BF00964832.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00964832 | en_US |
dc.identifier.source | Neurochemical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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