Chromosomal location of human genes encoding major heat-shock protein HSP70
dc.contributor.author | Drabkin, Harry A. | en_US |
dc.contributor.author | Chu, Ernest H. Y. | en_US |
dc.contributor.author | Kao, Fa -Ten | en_US |
dc.contributor.author | Hartz, Judith | en_US |
dc.contributor.author | Harrison, Gail Singer | en_US |
dc.contributor.author | Hart, Iris M. | en_US |
dc.contributor.author | Wu, Barbara J. | en_US |
dc.contributor.author | Morimoto, Richard I. | en_US |
dc.date.accessioned | 2006-09-11T16:10:31Z | |
dc.date.available | 2006-09-11T16:10:31Z | |
dc.date.issued | 1987-03 | en_US |
dc.identifier.citation | Harrison, Gail Singer; Drabkin, Harry A.; Kao, Fa -Ten; Hartz, Judith; Hart, Iris M.; Chu, Ernest H. Y.; Wu, Barbara J.; Morimoto, Richard I.; (1987). "Chromosomal location of human genes encoding major heat-shock protein HSP70." Somatic Cell and Molecular Genetics 13(2): 119-130. <http://hdl.handle.net/2027.42/45535> | en_US |
dc.identifier.issn | 0740-7750 | en_US |
dc.identifier.issn | 1572-9931 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45535 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3470951&dopt=citation | en_US |
dc.description.abstract | The HSP70 family of heat-shock proteins constitutes the major proteins synthesized in response to elevated temperatures and other forms of stress. In eukaryotes members of the HSP70 family also include a protein similar if not identical to bovine brain uncoating ATPase and glucose-regulated proteins. An intriguing relation has been established between expression of heat-shock proteins and transformation in mammalian cells. Elevated levels of HSP70 are found in some transformed cell lines, and viral and cellular gene products that are capable of transforming cells in vitro can also stimulate transcription of HSP70 genes. To determine the organization of this complex multigene family in the human genome, we used complementary approaches: Southern analysis and protein gels of Chinese hamster-human somatic cell hybrids, and in situ hybridization to human chromosomes. We demonstrate that functional genes encoding HSP70 proteins map to human chromosomes 6, 14, 21, and at least one other chromosome . | en_US |
dc.format.extent | 1400925 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Animal Anatomy / Morphology / Histology | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Plant Sciences | en_US |
dc.title | Chromosomal location of human genes encoding major heat-shock protein HSP70 | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, 1137 East Catherine Street, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2153 Sheridan Road, 60201, Evanston, Illinois | en_US |
dc.contributor.affiliationother | Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2153 Sheridan Road, 60201, Evanston, Illinois | en_US |
dc.contributor.affiliationother | Eleanor Roosevelt Institute for Cancer Research, 1899 Gaylord Street, 80206, Denver, Colorado; Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, Colorado | en_US |
dc.contributor.affiliationother | Eleanor Roosevelt Institute for Cancer Research, 1899 Gaylord Street, 80206, Denver, Colorado; Division of Medical Oncology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, Colorado | en_US |
dc.contributor.affiliationother | Eleanor Roosevelt Institute for Cancer Research, 1899 Gaylord Street, 80206, Denver, Colorado; Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, Colorado | en_US |
dc.contributor.affiliationother | Eleanor Roosevelt Institute for Cancer Research, 1899 Gaylord Street, 80206, Denver, Colorado | en_US |
dc.contributor.affiliationother | Eleanor Roosevelt Institute for Cancer Research, 1899 Gaylord Street, 80206, Denver, Colorado | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3470951 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45535/1/11188_2005_Article_BF01534692.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01534692 | en_US |
dc.identifier.source | Somatic Cell and Molecular Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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