Chromosomal localization of 15 ion channel genes
dc.contributor.author | Russell, Mark W. | en_US |
dc.contributor.author | Manoir, Stan | en_US |
dc.contributor.author | Munroe, David J. | en_US |
dc.contributor.author | Collins, Francis S. | en_US |
dc.contributor.author | Brody, Lawrence C. | en_US |
dc.date.accessioned | 2006-09-11T16:11:26Z | |
dc.date.available | 2006-09-11T16:11:26Z | |
dc.date.issued | 1996-09 | en_US |
dc.identifier.citation | Russell, Mark W. W.; Manoir, Stan; Munroe, David J.; Collins, Francis S.; Brody, Lawrence C.; (1996). "Chromosomal localization of 15 ion channel genes." Somatic Cell and Molecular Genetics 22(5): 425-431. <http://hdl.handle.net/2027.42/45548> | en_US |
dc.identifier.issn | 0740-7750 | en_US |
dc.identifier.issn | 1572-9931 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/45548 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9039851&dopt=citation | en_US |
dc.description.abstract | Several human Mendelian diseases, including the long-QT syndrome, malignant hyperthermia, and episodic ataxia/myokymia syndrome, have recently been demonstrated to be due to mutations in ion channel genes. Systematic mapping of ion channel genes may therefore reveal candidates for other heritable disorders. In this study, the GenBank and dbEST databases were used to identify members of several ion channel families (voltage-gated calcium and sodium cardiac chloride, and all classes of potassium channels). Genes and ESTs without prior map localization were identified based on GDB and OWL database information and 15 genes and ESTs were selected for mapping. Of these 15, only the serotonin receptor 5HT3R had been previously mapped to a chromosome. A somatic cell hybrid panel (SCH) was screened with an STS from each gene and, if necessary, the results verified by a second SCH panel. For three ESTs, rodent derived PCR products of the same size as the human STS precluded SCH mapping. For these three, human Pl clones were isolated and the genomic location was determined by metaphase FISH. These genes and ESTs can now be further evaluated as candidate genes for inherited cardiac, neuromuscular, and psychiatric disorders mapped to these chromosomes. Furthermore, the ESTs developed in this study can be used to isolate genomic clones, enabling the determination of each transcript's genomic structure and physical map location. This approach may also be applicable to other gene families and may aid in the identification of candidate genes for groups of related heritable disorders. | en_US |
dc.format.extent | 1314163 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Plant Sciences | en_US |
dc.subject.other | Human Genetics | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Animal Anatomy / Morphology / Histology | en_US |
dc.title | Chromosomal localization of 15 ion channel genes | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Deparments of Pediatrics and Communicable Diseases. Human Genetics, and Internal Medicme, University of Michigan, Ann Arbor, Michigan; Laboratory of Gene Transfer, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | Diagnostic Development Branch, The National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts | en_US |
dc.contributor.affiliationother | Laboratory of Gene Transfer, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | Laboratory of Gene Transfer, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9039851 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/45548/1/11188_2006_Article_BF02369898.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02369898 | en_US |
dc.identifier.source | Somatic Cell and Molecular Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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