The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy
dc.contributor.author | Sima, Anders A. F. | en_US |
dc.contributor.author | Brown, M. B. | en_US |
dc.contributor.author | Prashar, A. | en_US |
dc.contributor.author | Chakrabarti, Subrata | en_US |
dc.contributor.author | Laudadio, C. | en_US |
dc.contributor.author | Greene, Douglas A. | en_US |
dc.date.accessioned | 2006-09-11T17:17:17Z | |
dc.date.available | 2006-09-11T17:17:17Z | |
dc.date.issued | 1992-06 | en_US |
dc.identifier.citation | Sima, A. A. F.; Brown, M. B.; Prashar, A.; Chakrabarti, S.; Laudadio, C.; Greene, D. A.; (1992). "The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy." Diabetologia 35(6): 560-569. <http://hdl.handle.net/2027.42/46025> | en_US |
dc.identifier.issn | 0012-186X | en_US |
dc.identifier.issn | 1432-0428 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46025 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1612230&dopt=citation | en_US |
dc.description.abstract | The nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated previously in a systematic manner. Morphometric parameters of nerve fibre damage were measured in four separate fascicles from bilateral sural nerve specimens obtained post-mortem from 13 diabetic and 13 non-diabetic subjects. Intra- and inter-individual coefficients of variation were computed and compared to the magnitude of the differences between normal and diabetic subjects. Several morphometric variables emerged as highly sensitive and reproducible measures of nerve fibre damage suitable for clinical studies of diabetic peripheral polyneuropathy. These observations provide a rational basis for the design of future clinical trials employing morphometric end-points. | en_US |
dc.format.extent | 2493993 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Morphometry | en_US |
dc.subject.other | Diabetes Mellitus | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Human Physiology | en_US |
dc.subject.other | Internal Medicine | en_US |
dc.subject.other | Metabolic Diseases | en_US |
dc.subject.other | Neuropathy | en_US |
dc.subject.other | Sural Nerve | en_US |
dc.title | The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Pathology, Biostatistics and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; The Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Departments of Pathology, Biostatistics and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; The Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Departments of Pathology, Biostatistics and Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; The Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | School of Life and Health Sciences, University of Delaware, Newark, Delaware, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1612230 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46025/1/125_2004_Article_BF00400485.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00400485 | en_US |
dc.identifier.source | Diabetologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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