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Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy

dc.contributor.authorLi, F.en_US
dc.contributor.authorSzabó, C.en_US
dc.contributor.authorPacher, P.en_US
dc.contributor.authorSouthan, G. J.en_US
dc.contributor.authorAbatan, O. I.en_US
dc.contributor.authorCharniauskaya, T.en_US
dc.contributor.authorStevens, Martin J.en_US
dc.contributor.authorObrosova, I. G.en_US
dc.date.accessioned2006-09-11T17:18:01Z
dc.date.available2006-09-11T17:18:01Z
dc.date.issued2004-04en_US
dc.identifier.citationLi, F.; Szabó, C.; Pacher, P.; Southan, G. J.; Abatan, O. I.; Charniauskaya, T.; Stevens, M. J.; Obrosova, I. G.; (2004). "Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy." Diabetologia 47(4): 710-717. <http://hdl.handle.net/2027.42/46035>en_US
dc.identifier.issn1432-0428en_US
dc.identifier.issn0012-186Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46035
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15298348&dopt=citationen_US
dc.description.abstractPoly(ADP-ribose) polymerase activation depletes NAD + and high-energy phosphates, activates protein kinase C, and affects gene expression in various tissues. This study was designed to characterise the effects of the potent, orally active poly(ADP-ribose) polymerase inhibitor PJ34 in the Wistar rat model of early diabetic neuropathy.en_US
dc.format.extent270863 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherPoly(ADP-ribose) Polymeraseen_US
dc.subject.otherPeripheral Diabetic Neuropathyen_US
dc.subject.otherEnergy Stateen_US
dc.subject.otherNerve Blood Flowen_US
dc.subject.otherMedicineen_US
dc.subject.otherMotor and Sensory Nerve Conductionen_US
dc.subject.otherOxidative and Nitrosative Stressen_US
dc.subject.otherPJ34en_US
dc.subject.otherRaten_US
dc.subject.otherSorbitol Pathway of Glucose Metabolismen_US
dc.subject.otherStreptozotocin-diabetesen_US
dc.titleEvaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathyen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Rm 5570, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationotherInotek Pharmaceuticals Corporation, Beverly, Massachusetts, USAen_US
dc.contributor.affiliationotherInotek Pharmaceuticals Corporation, Beverly, Massachusetts, USAen_US
dc.contributor.affiliationotherInotek Pharmaceuticals Corporation, Beverly, Massachusetts, USA; Institute of Human Physiology and Experimental Research, Semmelweis University Medical School, Budapest, Hungaryen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid15298348en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46035/1/125_2004_Article_1356.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00125-004-1356-0en_US
dc.identifier.sourceDiabetologiaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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