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The IA-2 interactome
dc.contributor.authorNotkins, A. L.en_US
dc.contributor.authorCai, T.en_US
dc.contributor.authorHu, Y. F.en_US
dc.contributor.authorZhang, H. L.en_US
dc.contributor.authorHarashima, S.en_US
dc.date.accessioned2006-09-11T17:18:06Z
dc.date.available2006-09-11T17:18:06Z
dc.date.issued2005-12en_US
dc.identifier.citationHu, Y. F.; Zhang, H. L.; Cai, T.; Harashima, S.; Notkins, A. L.; (2005). "The IA-2 interactome." Diabetologia 48(12): 2576-2581. <http://hdl.handle.net/2027.42/46036>en_US
dc.identifier.issn0012-186Xen_US
dc.identifier.issn1432-0428en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46036
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16273344&dopt=citationen_US
dc.description.abstractIslet antigen-2 (IA-2), a major autoantigen in type 1 diabetes, is an enzymatically inactive member of the transmembrane protein tyrosine phosphatase (PTP) family. IA-2 is located in dense-core secretory vesicles and is involved in the regulation of insulin secretion. The present experiments were initiated to identify those proteins that interact with IA-2 (i.e. the IA-2 interactome) as a first step towards elucidating the mechanism(s) by which IA-2 influences insulin secretion and serves as an autoantigen.en_US
dc.format.extent231847 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherProtein Tyrosine Phosphataseen_US
dc.subject.otherYeast Two-hybriden_US
dc.subject.otherInteractomeen_US
dc.subject.otherAutoimmunityen_US
dc.subject.otherDense-core Secretory Vesiclesen_US
dc.subject.otherIA-2en_US
dc.subject.otherInsulin Secretionen_US
dc.subject.otherProtein Interactionen_US
dc.subject.otherType 1 Diabetesen_US
dc.titleThe IA-2 interactomeen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumLaboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI, USA,en_US
dc.contributor.affiliationotherExperimental Medicine Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, 20892, Bethesda, MD, USA,en_US
dc.contributor.affiliationotherExperimental Medicine Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, 20892, Bethesda, MD, USA,en_US
dc.contributor.affiliationotherExperimental Medicine Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, 20892, Bethesda, MD, USA,en_US
dc.contributor.affiliationotherExperimental Medicine Section, Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, 20892, Bethesda, MD, USA,en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid16273344en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46036/1/125_2005_Article_37.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00125-005-0037-yen_US
dc.identifier.sourceDiabetologiaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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