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Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line
dc.contributor.authorBlume, R.en_US
dc.contributor.authorNihalani, D.en_US
dc.contributor.authorLechleiter, A.en_US
dc.contributor.authorOetjen, E.en_US
dc.contributor.authorHolzman, Lawrence B.en_US
dc.contributor.authorKnepel, W.en_US
dc.date.accessioned2006-09-11T17:18:10Z
dc.date.available2006-09-11T17:18:10Z
dc.date.issued2006-02en_US
dc.identifier.citationOetjen, E.; Lechleiter, A.; Blume, R.; Nihalani, D.; Holzman, L.; Knepel, W.; (2006). "Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line." Diabetologia 49(2): 332-342. <http://hdl.handle.net/2027.42/46037>en_US
dc.identifier.issn1432-0428en_US
dc.identifier.issn0012-186Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46037
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16369771&dopt=citationen_US
dc.description.abstractThe activation of the transcription factor cyclic AMP response element binding protein (CREB) by protein kinase A is inhibited by the human orthologue of the mitogen-activated protein kinase, dual-leucine-zipper-bearing kinase (DLK) in teratocarcinoma cells. However, pancreatic beta cells are electrically excitable and a major pathway regulating CREB in these cells is membrane depolarisation, leading to calcium influx and activation of the calcium/calmodulin-dependent protein phosphatase calcineurin. Therefore, the effect of DLK on CREB activity induced by membrane depolarisation was investigated in the beta cell line HIT.en_US
dc.format.extent259446 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherCalcineurinen_US
dc.subject.otherBeta Cellsen_US
dc.subject.otherCyclic AMP Response Element Binding Proteinen_US
dc.subject.otherDual-leucine-Zipper-bearing Kinaseen_US
dc.subject.otherMembrane Depolarisationen_US
dc.titleInhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell lineen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA,en_US
dc.contributor.affiliationumDivision of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA,en_US
dc.contributor.affiliationotherMolecular Pharmacology, University of Göttingen, Robert-Koch Str. 40, 37099, Göttingen, Germany,en_US
dc.contributor.affiliationotherMolecular Pharmacology, University of Göttingen, Robert-Koch Str. 40, 37099, Göttingen, Germany,en_US
dc.contributor.affiliationotherMolecular Pharmacology, University of Göttingen, Robert-Koch Str. 40, 37099, Göttingen, Germany,en_US
dc.contributor.affiliationotherMolecular Pharmacology, University of Göttingen, Robert-Koch Str. 40, 37099, Göttingen, Germany,en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid16369771en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46037/1/125_2005_Article_87.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00125-005-0087-1en_US
dc.identifier.sourceDiabetologiaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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