View Item 

Show simple item record

Alcohol-inducible cytochrome P-450 (P-450 ALC )
dc.contributor.authorKoop, Dennis R.en_US
dc.contributor.authorCoon, Minor J.en_US
dc.date.accessioned2006-09-11T17:26:39Z
dc.date.available2006-09-11T17:26:39Z
dc.date.issued1987-05en_US
dc.identifier.citationCoon, Minor J.; Koop, Dennis R.; (1987). "Alcohol-inducible cytochrome P-450 (P-450 ALC )." Archives of Toxicology 60 (1-3): 16-21. <http://hdl.handle.net/2027.42/46156>en_US
dc.identifier.issn0340-5761en_US
dc.identifier.issn1432-0738en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46156
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3304205&dopt=citationen_US
dc.description.abstractOf the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3 a (P-450 ALC ) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol+0 2 +NADPH+H + → acetaldehyde +2H 2 O+NADP + . As judged by immuno-chemical quantitation, P-450 ALC is also induced in the animals by other diverse agents, including imidazole, trichlorethylene, acetone, pyrazole, and isoniazid. Evidence has been obtained for the occurrence of a protein immuno-chemically related to P-450 ALC in human liver microsomes and of a similar alcohol-inducible protein in the rat and in the normal and alcohol dehydrogenase-deficient deer-mouse. P-450 ALC catalyzes the activation of foreign compounds such as acetaminophen, various nitrosamines, and carbon tetrachloride and is therefore believed to play an important role in the enhanced toxicity of these substances accompanying alcohol administrationen_US
dc.format.extent821029 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherCytochrome P-450en_US
dc.subject.otherInductionen_US
dc.subject.otherButanolen_US
dc.subject.otherNitrosaminesen_US
dc.subject.otherCarbon Tetrachlorideen_US
dc.subject.otherEthanolen_US
dc.subject.otherCocaineen_US
dc.subject.otherAcetaminophenen_US
dc.subject.otherToxicityen_US
dc.subject.otherAllergologyen_US
dc.subject.otherCancer Researchen_US
dc.titleAlcohol-inducible cytochrome P-450 (P-450 ALC )en_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid3304205en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46156/1/204_2004_Article_BF00296940.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00296940en_US
dc.identifier.sourceArchives of Toxicologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
204_2004_Article_BF00296940.pdf
Size:
801.7KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.