Discriminative and reinforcing effects of brotizolam in rhesus monkeys
dc.contributor.author | Winger, Gail D. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Nader, Michael A. | en_US |
dc.contributor.author | Woolverton, William L. | en_US |
dc.date.accessioned | 2006-09-11T17:39:10Z | |
dc.date.available | 2006-09-11T17:39:10Z | |
dc.date.issued | 1991-02 | en_US |
dc.identifier.citation | Nader, Michael A.; Winger, Gail; Woods, James H.; Woolverton, William L.; (1991). "Discriminative and reinforcing effects of brotizolam in rhesus monkeys." Psychopharmacology 103(2): 166-171. <http://hdl.handle.net/2027.42/46334> | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46334 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2027918&dopt=citation | en_US |
dc.description.abstract | The reinforcing and discriminative stimulus effects of brotizolam, a benzodiazepine-hypnotic, were evaluated in rhesus monkeys. In one experiment, separate groups of monkeys ( N =3/group) were trained to discriminate pentobarbital (10 mg/kg, IG) or d -amphetamine (0.56–1.0 mg/kg, IG) from saline, in a discrete-trials avoidance/escape paradigm. Pentobarbital (5.6–10 mg/kg), diazepam (1.0–1.7 mg/kg), and brotizolam (0.3–1.7 mg/kg) resulted in 100% drug-lever responding in all three pentobarbital-trained monkeys. In d -amphetamine-trained monkeys brotizolam administration resulted only in saline-lever responding. In another experiment, monkeys were surgically prepared with indwelling intravenous catheters and lever pressing resulted in an injection of 0.1 mg/kg/injection sodium methohexital under a fixed-ratio 10 (FR 10) schedule. Pentobarbital (0.01–0.3 mg/kg/injection) and diazepam (0.003–0.10 mg/kg/injection) maintained responding above saline control levels when substituted for methohexital. Brotizolam (0.001–0.01 mg/kg/injection) resulted in more injections received compared to saline, but fewer injections compared to pentobarbital or diazepam. Thus, results from the present experiment suggest that brotizolam would have pentobarbital-like subjective effects. However, the abuse liability of brotizolam may be lower than that for diazepam. | en_US |
dc.format.extent | 953347 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Self-administration | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Rhesus Monkeys | en_US |
dc.subject.other | Pentobarbital | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Drug Discrimination | en_US |
dc.subject.other | Brotizolam | en_US |
dc.title | Discriminative and reinforcing effects of brotizolam in rhesus monkeys | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, The University of Chicago, 60637, Chicago, IL, USA; Department of Pharmacological and Physiological Sciences, Pritzker School of Medicine, The University of Chicago, 60637, Chicago, IL, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, The University of Chicago, 60637, Chicago, IL, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2027918 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46334/1/213_2005_Article_BF02244198.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02244198 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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