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Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats
dc.contributor.authorRobinson, Terry E.en_US
dc.contributor.authorPaulson, Pamela E.en_US
dc.date.accessioned2006-09-11T17:39:20Z
dc.date.available2006-09-11T17:39:20Z
dc.date.issued1991-05en_US
dc.identifier.citationPaulson, Pamela E.; Robinson, Terry E.; (1991). "Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats." Psychopharmacology 104(1): 140-141. <http://hdl.handle.net/2027.42/46336>en_US
dc.identifier.issn0033-3158en_US
dc.identifier.issn1432-2072en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46336
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1882000&dopt=citationen_US
dc.description.abstractRepeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with systemic injections of AMPH does produce a significant enhancement in the locomotor stimulant effects produced by intra-accumbens AMPH given 21 days after the last pretreatment injection of AMPH. These data support the hypothesis that neural adaptations in dopamine (DA) terminal fields are sufficient for the expression of AMPH sensitization, although an action on DA cell bodies may be required for the induction of AMPH sensitization.en_US
dc.format.extent276961 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherNucleus Accumbensen_US
dc.subject.otherDopamineen_US
dc.subject.other“Reverse Tolerance”en_US
dc.subject.otherPsychiatryen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherSensitizationen_US
dc.subject.otherLocomotor Activityen_US
dc.subject.otherMicroinjectionen_US
dc.titleSensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in ratsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, The University of Michigan, 1103 East Huron Street, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Psychology, The University of Michigan, 1103 East Huron Street, 48109, Ann Arbor, MI, USA; Neuroscience Program, The University of Michigan, 1103 East Huron Street, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid1882000en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46336/1/213_2005_Article_BF02244569.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF02244569en_US
dc.identifier.sourcePsychopharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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