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Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex
dc.contributor.authorFinlay, J. M.en_US
dc.contributor.authorSucharski, I. L.en_US
dc.contributor.authorClinton, Sarah M.en_US
dc.date.accessioned2006-09-11T17:42:15Z
dc.date.available2006-09-11T17:42:15Z
dc.date.issued2006-01en_US
dc.identifier.citationClinton, S. M.; Sucharski, I. L.; Finlay, J. M.; (2006). "Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex." Psychopharmacology 183(4): 404-412. <http://hdl.handle.net/2027.42/46372>en_US
dc.identifier.issn1432-2072en_US
dc.identifier.issn0033-3158en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46372
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16307295&dopt=citationen_US
dc.description.abstractThe density of tyrosine hydroxylase-immunoreactive (TH-IR) axons in the prefrontal cortex of schizophrenic subjects may be reduced by as much as 50% in the deep cortical layers (Am J Psychiatry 156:1580–1589, 1999). Previously, we demonstrated that ~60% loss of TH-IR axons in the rat medial prefrontal cortex (mPFC) decreases local basal and stress-evoked extracellular dopamine (DA) concentrations, suggesting that moderate loss of DA axons in the mPFC is sufficient to alter the neurochemical activity of the remaining DA neurons (Neuroscience 93:497–505, 1999).en_US
dc.format.extent200805 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherT-mazeen_US
dc.subject.other6-Hydroxydopamineen_US
dc.subject.otherNorepinephrineen_US
dc.subject.otherDelayed Responseen_US
dc.titleDesipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortexen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA,en_US
dc.contributor.affiliationotherPsychology Department, University of Delaware, Newark, DE, 19716, USA,en_US
dc.contributor.affiliationotherDepartment of Psychology, Western Washington University, 220 Miller Hall, MS 9089, Bellingham, WA, 98225, USA,en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid16307295en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46372/1/213_2005_Article_221.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00213-005-0221-2en_US
dc.identifier.sourcePsychopharmacologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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