Psychomotor stimulant self administration as a function of dosage per injection in the Rhesus monkey
dc.contributor.author | Hitomi, M. | en_US |
dc.contributor.author | Wilson, Marvin C. | en_US |
dc.contributor.author | Schuster, Charles R. | en_US |
dc.date.accessioned | 2006-09-11T17:42:45Z | |
dc.date.available | 2006-09-11T17:42:45Z | |
dc.date.issued | 1971-09 | en_US |
dc.identifier.citation | Wilson, M. C.; Hitomi, M.; Schuster, C. R.; (1971). "Psychomotor stimulant self administration as a function of dosage per injection in the Rhesus monkey." Psychopharmacologia 22(3): 271-281. <http://hdl.handle.net/2027.42/46379> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46379 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4399836&dopt=citation | en_US |
dc.description.abstract | The relationships between drug dosage per injection and response rate, and drug dosage per injection and total daily drug intake were ascertained in Rhesus monkeys which self-administered cocaine, pipradrol, methylphenidate and phenmetrazine intravenously. The study demonstrated the monkeys would self-administer all of these compounds over a wide range of dosages. Furthermore, the magnitude of reinforcement, i.e., dosage per injection, and the rate of responding in self-administering these compounds were inversely related. However, total daily drug intake was independent of the dosage per injection over a wide range of dosages. The results indicate that either the subjects can compensate for large changes in unit dosage so that daily drug intake remains stable or that a direct effect of these compounds functions in limiting their self-administration. | en_US |
dc.format.extent | 618628 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Methylphenidate | en_US |
dc.subject.other | Pipradrol | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Self-Administration | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Cocaine | en_US |
dc.subject.other | Phenmetrazine | en_US |
dc.title | Psychomotor stimulant self administration as a function of dosage per injection in the Rhesus monkey | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Pharmacology Department, University of Michigan, Medical School, Ann Arbor, Michigan; Department of Pharmacology, School of Pharmacy, University of Mississippi, Oxford, Mississippi | en_US |
dc.contributor.affiliationum | Pharmacology Department, University of Michigan, Medical School, Ann Arbor, Michigan; Department of Psychiatry and Pharmacology, University of Chicago, Chicago, Illinois | en_US |
dc.contributor.affiliationum | Pharmacology Department, University of Michigan, Medical School, Ann Arbor, Michigan; Fujisawa Drug Company, Osaka, Japan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 4399836 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46379/1/213_2004_Article_BF00401789.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00401789 | en_US |
dc.identifier.source | Psychopharmacologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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