Effects of d -amphetamine, scopolamine, chlordiazepoxide and diphenylhydantoin on self-stimulation behavior and brain acetylcholine
dc.contributor.author | Domino, Edward F. | en_US |
dc.contributor.author | Olds, Marianne E. | en_US |
dc.date.accessioned | 2006-09-11T17:42:50Z | |
dc.date.available | 2006-09-11T17:42:50Z | |
dc.date.issued | 1972-03 | en_US |
dc.identifier.citation | Domino, Edward F.; Olds, Marianne E.; (1972). "Effects of d -amphetamine, scopolamine, chlordiazepoxide and diphenylhydantoin on self-stimulation behavior and brain acetylcholine." Psychopharmacologia 23(1): 1-16. <http://hdl.handle.net/2027.42/46380> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46380 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=5018976&dopt=citation | en_US |
dc.description.abstract | The effects of d-amphetamine (0.25–8), scopolamine (0.25–8), chlordiazepoxide (2.5–40), and diphenylhydantoin (25–75), given i.p. or s.c. on a mg/kg basis, were studied on self-stimulation behavior in the male albino rat. The dose-effect relationships, the role of baseline rates of responding and their effects on brain acetylcholine (ACh) were determined in rats trained to self-stimulate for electrical reward in the lateral posterior hypothalamus. The effects of d -amphetamine were both dose and baseline-rate dependent. Low-moderate doses (0.5–2.0 mg/kg inclusive) facilitated self-stimulation and larger doses (2.0 to 8.0 mg/kg) depressed responding. Baseline rates before d -amphetamine administration were extremely important in the effect observed. Low rates of responding were facilitated and high rates were depressed by this agent. The effects of scopolamine in a wide range of dosage were less consistent. A small dose (0.5 mg/kg) facilitated only transiently self-stimulation and larger doses (1–8 mg/kg) tended to depress this behavior. Baseline rate effects were less important but high-rate responders were usually depressed by scopolamine. | en_US |
dc.format.extent | 951493 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Self-Stimulation | en_US |
dc.subject.other | Acetylcholine | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Amphetamine | en_US |
dc.subject.other | Scopolamine | en_US |
dc.subject.other | Chlordiazepoxide | en_US |
dc.title | Effects of d -amphetamine, scopolamine, chlordiazepoxide and diphenylhydantoin on self-stimulation behavior and brain acetylcholine | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Michigan Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan, 48104, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Michigan Neuropsychopharmacology Research Program, Department of Pharmacology, University of Michigan, 48104, Ann Arbor, Michigan, USA; Division of Biology, California Institute of Technology, 91109, Pasadena, California, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 5018976 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46380/1/213_2004_Article_BF00414409.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00414409 | en_US |
dc.identifier.source | Psychopharmacologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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