The effects of stimulants and depressants on cocaine self-administration behavior in the Rhesus monkey
dc.contributor.author | Wilson, Marvin C. | en_US |
dc.contributor.author | Schuster, Charles R. | en_US |
dc.date.accessioned | 2006-09-11T17:43:25Z | |
dc.date.available | 2006-09-11T17:43:25Z | |
dc.date.issued | 1973-12 | en_US |
dc.identifier.citation | Wilson, M. C.; Schuster, C. R.; (1973). "The effects of stimulants and depressants on cocaine self-administration behavior in the Rhesus monkey." Psychopharmacologia 31(4): 291-304. <http://hdl.handle.net/2027.42/46388> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46388 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=4200380&dopt=citation | en_US |
dc.description.abstract | The effects of acute intramuscular pretreatment with several dosages of a variety of centrally acting compounds on intravenous cocaine self-administration behavior were ascertained. Pretreatment with morphine and pentobarbital produced no change in this behavior until dosages (2.0 mg/kg and 15.0 mg/kg respectively) were administered which grossly depressed grooming, exploratory, and locomotor activity behaviors, d -amphetamine (0.5–4.0 mg/kg) and phenmetrazine (2.0–12.0 mg/kg) pretreatment produced a dose-related decrease in cocaine self-administration. Trifluoperazine in dosages of 0.01–0.1 mg/kg increased the frequency of this behavior; whereas, higher dosages (0.2, 0.4 mg/kg) grossly depressed behavior. Imipramine (10–50 mg/kg) produced a dose-related decrease in cocaine self-administration. Potential mechanisms of these drug—behavior and drug—drug interactions are discussed. | en_US |
dc.format.extent | 862824 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Trifluoperazine | en_US |
dc.subject.other | Self-Administration | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Morphine | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Cocaine | en_US |
dc.subject.other | Pentobarbital | en_US |
dc.title | The effects of stimulants and depressants on cocaine self-administration behavior in the Rhesus monkey | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Pharmacology Department, University of Michigan Medical School, Ann Arbor, Michigan; Department of Pharmacology, School of Pharmacy, University of Mississippi, University, 38677, Mississippi | en_US |
dc.contributor.affiliationum | Pharmacology Department, University of Michigan Medical School, Ann Arbor, Michigan; Departments of Psychiatry and Pharmacology, University of Chicago, 60637, Chicago, Illinois | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 4200380 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46388/1/213_2004_Article_BF00421274.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00421274 | en_US |
dc.identifier.source | Psychopharmacologia | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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