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Brain acetylcholine in morphine pellet implanted rats given naloxone
dc.contributor.authorWilson, Ann E.en_US
dc.contributor.authorDomino, Edward F.en_US
dc.date.accessioned2006-09-11T17:43:33Z
dc.date.available2006-09-11T17:43:33Z
dc.date.issued1975-01en_US
dc.identifier.citationDomino, Edward F.; Wilson, Ann E.; (1975). "Brain acetylcholine in morphine pellet implanted rats given naloxone." Psychopharmacologia 41(1): 19-22. <http://hdl.handle.net/2027.42/46390>en_US
dc.identifier.issn0033-3158en_US
dc.identifier.issn1432-2072en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46390
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1168354&dopt=citationen_US
dc.description.abstractAdult male rats were implanted with intraventricular (ivt.) brain cannulae for injection of 5 Μg of acetylseco-hemicholinium-3 (acetylseco HC-3) as a means of studying acetylcholine (ACh) utilization during morphine withdrawal. Animals were made dependent by implanting s.c. two 75 mg morphine base pellets 24 hrs apart. On the 4th day animals were given 10 mg/kg of naloxone i.p. and/or 5 Μg acetylseco HC-3 ivt. and sacrificed by decapitation at various times. The brains were removed and assayed for ACh using a pyrolysis gas Chromatographie procedure. Total brain ACh before or after acetylseco-HC-3 was not altered at 5, 30, 60 and 120 but was decreased at 10 min after naloxone. These results are in sharp contrast to our previous data of enhanced brain ACh utilization in withdrawn rats made dependent to morphine by several weeks of twice daily injections. It is apparent that short term morphine pellet administration does not produce the marked neurochemical and behavioral changes of long term morphine injections.en_US
dc.format.extent358470 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherAcetylcholineen_US
dc.subject.otherNaloxoneen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherMorphineen_US
dc.subject.otherAcetylseco-Hemicholiniumen_US
dc.subject.otherPsychiatryen_US
dc.titleBrain acetylcholine in morphine pellet implanted rats given naloxoneen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid1168354en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46390/1/213_2004_Article_BF00421300.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00421300en_US
dc.identifier.sourcePsychopharmacologiaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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