Pargyline-induced increases in sensitivity to the effects of drugs on operant behavior in pigeons
dc.contributor.author | Carney, John M. | en_US |
dc.date.accessioned | 2006-09-11T17:44:12Z | |
dc.date.available | 2006-09-11T17:44:12Z | |
dc.date.issued | 1977-01 | en_US |
dc.identifier.citation | Carney, John M.; (1977). "Pargyline-induced increases in sensitivity to the effects of drugs on operant behavior in pigeons." Psychopharmacology 52(1): 97-102. <http://hdl.handle.net/2027.42/46399> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46399 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=403565&dopt=citation | en_US |
dc.description.abstract | Pigeons responded under a multiple fixedinterval 5-min, 30-response fixed-ratio schedule of food reinforcement. Acute pargyline doses between 10.0 and 50.0 mg/kg (i.m.), given immediately prior to the session, decreased responding. Daily administration of 50 mg/kg pargyline (24 mg/kg, every 12 h) initially decreased responding. Tolerance developed so that after 4 days of daily pargyline, responding had returned to control values. Chronic pargyline resulted in an enhanced sensitivity to the effects of d -amphetamine, ephedrine, tyramine, and morphine on schedule-controlled responding. Both d -amphetamine and pentobarbital increased fixed-interval responding at relatively low doses, while higher doses decreased responding. Daily pargyline resulted in an increased sensitivity to both the increases and decreases in response rates produced by d -amphetamine. In contrast, sensitivity to pentobarbital was not changed after daily pargyline. Ephedrine, tyramine, and morphine only decreased fixed-interval responding. Chronic pargyline resulted in an increased sensitivity to the response-rate decreasing effects of ephedrine, tyramine, and morphine. In addition to the increased sensitivity of fixed-interval responding to the effects of tyramine, the dose-effect curve for fixed-ratio responding was also a shifted to the left. Daily pargyline did not result in changes in sensitivity of fixedratio responding to the effects of the other drugs tested. | en_US |
dc.format.extent | 627876 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Pargyline | en_US |
dc.subject.other | Sympathomimetics | en_US |
dc.subject.other | Morphine | en_US |
dc.subject.other | Operant Behavior | en_US |
dc.subject.other | Pigeons | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Tolerance | en_US |
dc.subject.other | Pentobarbital | en_US |
dc.title | Pargyline-induced increases in sensitivity to the effects of drugs on operant behavior in pigeons | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Deparment of Pharmacology, The University of Michigan Medical School, 48004, Ann Arbor, Michigan, USA; Department of Pharmacology, Medical College of Virginia, 23298, Richmond, Virginia, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 403565 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46399/1/213_2004_Article_BF00426607.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00426607 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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