Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward
dc.contributor.author | Carroll, Bernard J. | en_US |
dc.contributor.author | Katz, Richard J. | en_US |
dc.date.accessioned | 2006-09-11T17:44:20Z | |
dc.date.available | 2006-09-11T17:44:20Z | |
dc.date.issued | 1978-01 | en_US |
dc.identifier.citation | Katz, R. J.; Carroll, B. J.; (1978). "Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward." Psychopharmacology 57(1): 39-42. <http://hdl.handle.net/2027.42/46401> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46401 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=96467&dopt=citation | en_US |
dc.description.abstract | Three centrally active inhibitors of phenylethanolamine-N-methyl transferase (PNMT; E.C.2.1.1.28), the terminal enzyme for epinephrine biosynthesis in the brain, produced dose-related decreases in rates of responding for rewarding brain stimulation in adult male rats. Decreases occurred at dosages that did not produce measurable neurologic impairment. This suggests a possible role for central epinephrine-containing neurons in the maintenance of reward-mediated behaviors. | en_US |
dc.format.extent | 347520 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | PNMT | en_US |
dc.subject.other | Brain Stimulation | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Reward | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Epinephrine | en_US |
dc.title | Inhibition of phenylethanolamine-N-methyltransferase and brain-stimulated reward | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Mental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 96467 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46401/1/213_2004_Article_BF00426955.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00426955 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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