Changes in locomotor activity and naloxone-induced jumping in mice produced by WIN 35,197-2 (Ethylketazocine) and morphine
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Tepper, Patricia | en_US |
dc.date.accessioned | 2006-09-11T17:44:37Z | |
dc.date.available | 2006-09-11T17:44:37Z | |
dc.date.issued | 1978-01 | en_US |
dc.identifier.citation | Tepper, Patricia; Woods, James H.; (1978). "Changes in locomotor activity and naloxone-induced jumping in mice produced by WIN 35,197-2(Ethylketazocine) and morphine." Psychopharmacology 58 (2): 125-129. <http://hdl.handle.net/2027.42/46405> | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46405 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=98778&dopt=citation | en_US |
dc.description.abstract | Acute i.p. administration of morphine or cocaine produced increase in locomotor activity in Swiss-Webster female mice that were maximal at 32–100 mg/kg for morphine and at 32 mg/kg for cocaine. WIN 35,197-2 produced dose-dependent decreases in locomotor activity from 3.2–32 mg/kg. Chronic administration of WIN 35,197-2 led to a 6–10 fold shift to the right in the locomotor activity decreasing effect of the drug, but WIN 35,197-2-tolerant mice retained their sensitivity to the locomotor stimulant effects of morphine and cocaine. Acute administration of WIN 35,197-2 failed to sensitize mice to naloxone-induced jumping, although morphine did so. Chronic administration of WIN 35,197-2 did lead to sensitization to naloxone, but WIN 35,197-2 was much less efficacious in this regard than morphine. These behavioral effects of WIN 35,197-2 may be helpful in the classification of modes of action of different narcotic agonists. | en_US |
dc.format.extent | 397220 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Mice | en_US |
dc.subject.other | WIN 35,197-2 | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Naloxone-induced Jumping | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Locomotor Activity | en_US |
dc.subject.other | Morphine | en_US |
dc.subject.other | Cocaine | en_US |
dc.title | Changes in locomotor activity and naloxone-induced jumping in mice produced by WIN 35,197-2 (Ethylketazocine) and morphine | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Psychology and Pharmacology, University of Michigan, 48109, Ann Arbor, Michigan, USA; 1110 Oxford House, 37212, Nashville, Tenn., USA | en_US |
dc.contributor.affiliationum | Departments of Psychology and Pharmacology, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 98778 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46405/1/213_2004_Article_BF00426894.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00426894 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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