Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat
dc.contributor.author | Domino, Edward F. | en_US |
dc.contributor.author | Demetriou, Sandra | en_US |
dc.contributor.author | Kovacic, Beverly | en_US |
dc.contributor.author | Ruffing, Diane M. | en_US |
dc.date.accessioned | 2006-09-11T17:44:50Z | |
dc.date.available | 2006-09-11T17:44:50Z | |
dc.date.issued | 1979-01 | en_US |
dc.identifier.citation | Ruffing, Diane; Kovacic, Beverly; Demetriou, Sandra; Domino, Edward F.; (1979). "Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat." Psychopharmacology 62(3): 207-210. <http://hdl.handle.net/2027.42/46408> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46408 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=111285&dopt=citation | en_US |
dc.description.abstract | The narcotic antagonist naloxone was tested to determine its possible interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained to press a bar on a fixed-ratio four schedule (FR 4 ), i.e., every fourth press earned a reward of 0.01 ml sugar sweetened milk. LSD (0.1 mg/kg) or increasing doses of DMT (1.0, 3.2, and 10.0 mg/kg) were administered i.p. to disrupt food-rewarded fixed ratio bar pressing in a dose related fashion. Pretreatment (5–10 min) with behaviorally ineffective doses of naloxone (1.0–5.6 mg/kg) dramatically enhanced the effects of DMT and LSD. The content of DMT in the brain and liver of rats injected with DMT alone (10 mg/kg) and with a 5 min pretreatment of naloxone (3.2 mg/kg) was determined by radiochemical analysis at 30 and 90 min after 14 C-DMT injection. There was no significant difference for either brain or liver 14 C-DMT levels when control DMT rats were compared with the naloxone pretreated rats. These results seem to rule out interference by naloxone with the metabolism of DMT as a mechanism of the observed behavioral potentiation. | en_US |
dc.format.extent | 397220 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | LSD | en_US |
dc.subject.other | Liver | en_US |
dc.subject.other | Rat | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Naloxone | en_US |
dc.subject.other | Potentiation | en_US |
dc.subject.other | DMT | en_US |
dc.subject.other | FR 4 Operant Behavior | en_US |
dc.subject.other | Brain | en_US |
dc.title | Naloxone enhancement of DMT and LSD-25 induced suppression of food-rewarded bar pressing behavior in the rat | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, Lafayette Clinic, 951 E. Lafayette, 48207, Detroit, Michigan, USA; The University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, Lafayette Clinic, 951 E. Lafayette, 48207, Detroit, Michigan, USA; The University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, Lafayette Clinic, 951 E. Lafayette, 48207, Detroit, Michigan, USA; The University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, Lafayette Clinic, 951 E. Lafayette, 48207, Detroit, Michigan, USA; The University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 111285 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46408/1/213_2004_Article_BF00431949.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00431949 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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