The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey
dc.contributor.author | Tarika, Janet S. | en_US |
dc.contributor.author | Winger, Gail D. | en_US |
dc.date.accessioned | 2006-09-11T17:45:15Z | |
dc.date.available | 2006-09-11T17:45:15Z | |
dc.date.issued | 1980-10 | en_US |
dc.identifier.citation | Tarika, Janet S.; Winger, Gail; (1980). "The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey." Psychopharmacology 70(2): 201-208. <http://hdl.handle.net/2027.42/46414> | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46414 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6776581&dopt=citation | en_US |
dc.description.abstract | Physical dependence on ethanol was produced in four rhesus monkeys by IV ethanol administration every 8 h. Ethanol was administered on each occasion until the eyeblink reflex was lost. Evidence of physical dependence development, in the form of tremoring 8 h after an infusion, appeared on day 8 of chronic administration. Abrupt cessation of ethanol administration following 16 days of chronic administration was accompanied by moderate to severe tremoring, retching, vomiting, and one or more convulsions. Peak withdrawal occurred between 12 and 32 h after abrupt discontinuation of ethanol administration, and decreased over a period of 64–204 h. Ethanol dependence was then reinstated. Once every 3–4 days, ethanol was withheld for 16 h. Withdrawal signs were scored for the first 12 h of this period, and then a test dose of ethanol, phenobarbital, or baclofen was administered. Withdrawal or intoxication signs were scored over the next 4 h, at which time ethanol administration was resumed. Both ethanol and phenobarbital suppressed ethanol withdrawal sign in a dose-related manner, and produced dose-related intoxication. Baclofen was largely ineffective in reducing withdrawal-induced tremors, although it was capable of producing sedation of a different type than that produced by phenobarbital and ethanol. | en_US |
dc.format.extent | 879319 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Baclofen | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Ethanol Physical Dependence | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Phenobarbital | en_US |
dc.subject.other | Rhesus Monkeys | en_US |
dc.title | The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Psychology and Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Departments of Psychology and Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6776581 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46414/1/213_2004_Article_BF00435315.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00435315 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.