Antagonism of the discriminative effects of ethylketazocine, cyclazocine, and nalorphine in macaques
dc.contributor.author | Young, Alice M. | en_US |
dc.contributor.author | Stephens, Kenneth R. | en_US |
dc.date.accessioned | 2006-09-11T17:46:36Z | |
dc.date.available | 2006-09-11T17:46:36Z | |
dc.date.issued | 1984-09 | en_US |
dc.identifier.citation | Young, Alice M.; Stephens, Kenneth R.; (1984). "Antagonism of the discriminative effects of ethylketazocine, cyclazocine, and nalorphine in macaques." Psychopharmacology 84(3): 356-361. <http://hdl.handle.net/2027.42/46433> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46433 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6151208&dopt=citation | en_US |
dc.description.abstract | dl -Ethylketazocine (EKC, 0.01 mg/kg) and saline were established as discriminative stimuli for food-maintained responding in macaque monkeys. Thirty consecutive presses on a right or left lever were reinforced with food, contingent on whether EKC or saline were administered before the session. For tests of antagonism, naltrexone, or UM 979 [( l )-5,9-alpha-dimethyl-2-(3-furylmethyl)-2′-hydroxy-6,7-benzomorphan] was administered concomitantly with EKC, dl -cyclazocine, or nalorphine. Both antagonists blocked completely the EKC discriminative stimulus. The antagonism of the stimulus and rate-altering effects of EKC was surmountable, with considerable intersubject variability in the magnitude of the EKC dose increase required to overcome the blockade. Cyclazocine and nalophine, mixed agonist-antagonist opioids that share stimulus properties with EKC, were also susceptible to antagonism. Naltrexone antagonized completely the EKC stimulus effects of nalorphine; naltrexone and UM 979 antagonized completely the EKC stimulus effects of cyclazocine. Naltrexone antagonism of the cyclazocine stimulus was not surmountable, due to a lack of antagonism of the rate-decreasing effects of high cyclazocine doses. | en_US |
dc.format.extent | 710483 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Naltrexone | en_US |
dc.subject.other | Cyclazocine | en_US |
dc.subject.other | ϰ Opioids | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Drug Discrimination | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Ethylketazocine | en_US |
dc.subject.other | Nalorphine | en_US |
dc.subject.other | Macaque Monkeys | en_US |
dc.title | Antagonism of the discriminative effects of ethylketazocine, cyclazocine, and nalorphine in macaques | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA; Department of Psychology, Wayne State University, 71 West Warren Avenue, 48202, Detroit, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical School, 48109, Ann Arbor, MI, USA; Mantech/CADCOM, Suite 1111 Century Mall Building, 2341 Jefferson Davis Highway, 22202, Arlington, VA, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6151208 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46433/1/213_2004_Article_BF00555213.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00555213 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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