Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats
dc.contributor.author | Robinson, Terry E. | en_US |
dc.date.accessioned | 2006-09-11T17:46:40Z | |
dc.date.available | 2006-09-11T17:46:40Z | |
dc.date.issued | 1984-12 | en_US |
dc.identifier.citation | Robinson, Terry E.; (1984). "Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats." Psychopharmacology 84(4): 466-475. <http://hdl.handle.net/2027.42/46434> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46434 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6441946&dopt=citation | en_US |
dc.description.abstract | Factors influencing the behavioral sensitization (“reverse tolerance”) produced by intermittent amphetamine (AMPH) injections were studied by quantifying rotational behavior in rats that had a unilateral 6-hydroxydopamine lesion of the substantia nigra. The results indicate that (1) a single injection of a low dose of AMPH enhances rotational behavior induced by a second injection of AMPH for up to 12 weeks; (2) multiple, weekly injections of AMPH produce a progressive enhancement in rotational behavior, over-and-above that produced by a single injection; (3) female rats show more robust sensitization than males following single or multiple injections of AMPH; (4) this sex difference may be due to the suppression of sensitization by an androgen, because removal of testicular hormones potentiates sensitization; (5) the long-lasting sensitization of rotational behavior produced by infrequent injections of AMPH is not due to drug-environment conditioning effects, but perhaps to a persistent AMPH-induced change(s) in brain catecholamine systems; and (6) a simple change in DA receptors is probably no involved, because the sensitization produced by infrequent injections of AMPH does not influence the rotation produced by a subsequent injection of apomorphine. The results illustrate an intriguing example of neuroplasticity that may have clinical relevance. | en_US |
dc.format.extent | 1211951 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Apomorphine | en_US |
dc.subject.other | Reverse Tolerance | en_US |
dc.subject.other | 6-Hydroxydopamine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Gonadal Hormones | en_US |
dc.subject.other | Sensitization | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Rat | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Rotational Behavior | en_US |
dc.subject.other | Amphetamine | en_US |
dc.subject.other | Sex Differences | en_US |
dc.subject.other | Amphetamine Psychosis | en_US |
dc.subject.other | Conditioning | en_US |
dc.subject.other | Dopamine | en_US |
dc.title | Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Psychology, Department and Neuroscience Laboratory Building, The University of Michigan, 1103 E. Huron Street, 48104-1687, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6441946 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46434/1/213_2004_Article_BF00431451.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00431451 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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