Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP
dc.contributor.author | Koek, Wouter | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Jacobson, Arthur E. | en_US |
dc.contributor.author | Rice, Kenner C. | en_US |
dc.date.accessioned | 2006-09-11T17:47:35Z | |
dc.date.available | 2006-09-11T17:47:35Z | |
dc.date.issued | 1987-12 | en_US |
dc.identifier.citation | Koek, W.; Woods, J. H.; Jacobson, A. E.; Rice, K. C.; (1987). "Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP." Psychopharmacology 93(4): 437-442. <http://hdl.handle.net/2027.42/46447> | en_US |
dc.identifier.issn | 1432-2072 | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46447 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2893414&dopt=citation | en_US |
dc.description.abstract | Pigeons were trained to discriminate either a fixed dose of PCP (1 mg/kg; n =3) or a progressively decreasing dose (1-0.56–0.32 mg/kg; n =4) from saline. Lowering of the training dose shifted the dose-effect curve for PCP's discriminative stimulus effects about 5-fold to the left, in a parallel manner, but did not decrease the accuracy of the discrimination performance and did not significantly increase the extent to which pentobarbital and chlordiazepoxide produced PCP-appropriate responding. Dose-effect curves based on binary generalization data were evaluated statistically with new methods that may be more appropriate than those used previously. Metaphit, a proposed PCP-receptor acylator, and 2-amino-5-phosphonovalerate (AP5), an N-methyl- d -aspartate (NMDA) antagonist, produced complete PCP-appropriate responding in the high training dose group only at doses that suppressed the rate of responding and that produced ataxia. However, 4-fold lower doses of metaphit and AP5, which did not produce directly observable behavioral effects, were found to substitute completely for PCP in the low training dose group. These data support the notion that PCP, metaphit, and AP5 have a common discriminative effect in pigeons. | en_US |
dc.format.extent | 695728 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Chlordiazepoxide | en_US |
dc.subject.other | Phencyclidine | en_US |
dc.subject.other | Metaphit | en_US |
dc.subject.other | Receptor Acylator | en_US |
dc.subject.other | Pharmacological Specificity | en_US |
dc.subject.other | Drug Discrimination | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Excitatory Amino Acids | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Training Dose | en_US |
dc.subject.other | Threshold Dose Analysis | en_US |
dc.subject.other | 2-Amino-5-phosphonovalerate (AP5) | en_US |
dc.subject.other | Pentobarbital | en_US |
dc.subject.other | Pigeons | en_US |
dc.title | Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, M6322 Medical Science Building I, Ann Arbor, MI, USA; Department of Psychology, University of Michigan, M6322 Medical Science Building I, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, M6322 Medical Science Building I, Ann Arbor, MI, USA; FONDAX — Groupe de Recherche SERVIER, 7 Rue Ampere, F-92800, Puteaux, France | en_US |
dc.contributor.affiliationother | Laboratory of Chemistry, NIADDKD, National Institutes of Health, Bethesda, MD, USA | en_US |
dc.contributor.affiliationother | Laboratory of Chemistry, NIADDKD, National Institutes of Health, Bethesda, MD, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 2893414 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46447/1/213_2004_Article_BF00207232.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00207232 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.