Plasma protein binding of prednisolone in normal volunteers and arthritic patients
dc.contributor.author | Ağabeyoğlu, I. T. | en_US |
dc.contributor.author | Bergstrom, Richard F. | en_US |
dc.contributor.author | Gillespie, William R. | en_US |
dc.contributor.author | Wagner, John G. | en_US |
dc.contributor.author | Kay, Donald R. | en_US |
dc.date.accessioned | 2006-09-11T18:01:28Z | |
dc.date.available | 2006-09-11T18:01:28Z | |
dc.date.issued | 1979-11 | en_US |
dc.identifier.citation | Ağabeyoğlu, I. T.; Bergstrom, R. F.; Gillespie, W. R.; Wagner, J. G.; Kay, D. R.; (1979). "Plasma protein binding of prednisolone in normal volunteers and arthritic patients." European Journal of Clinical Pharmacology 16(6): 399-404. <http://hdl.handle.net/2027.42/46638> | en_US |
dc.identifier.issn | 0031-6970 | en_US |
dc.identifier.issn | 1432-1041 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46638 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=527636&dopt=citation | en_US |
dc.description.abstract | The plasma binding of prednisolone was studied in twenty normal volunteers and twenty rheumatoid arthritis patients. An in vitro assessment of the binding following the addition of prednisolone, prednisone, and hydrocortisone to the plasmas obtained from the subjects showed significant differences in the percentage of prednisolone bound. However, the differences observed were regarded as clinically insignificant. The plasma protein binding was determined by an in vitro equilibrium dialysis of the individual plasma samples at 37° C. Prednisolone levels on both sides of the dialysis membrane were determined using radioactivity and HPLC analytical methodologies. The percentages of prednisolone bound calculated from the analytical results of either the radiochemical or HPLC method were not significantly different. The change in the percentage of prednisolone bound to plasma proteins was studied as a function of the total prednisolone plasma concentration in a normal volunteer and in a systemic lupus erythematosis patient. As a result of prednisolone binding to both transcortin and albumin, the binding of prednisolone changes as a function of prednisolone concentration. The binding data were fitted using nonlinear least squares regression, and the affinity constants for the binding of prednisolone to transcortin and albumin were estimated. | en_US |
dc.format.extent | 823016 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Transcortin | en_US |
dc.subject.other | Rheumatoid Arthritis | en_US |
dc.subject.other | Prednisolone | en_US |
dc.subject.other | Plasma Protein Binding | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Prednisone | en_US |
dc.subject.other | Albumin | en_US |
dc.title | Plasma protein binding of prednisolone in normal volunteers and arthritic patients | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan, Medical Center, Ann Arbor, Michigan, USA; College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan, Medical Center, Ann Arbor, Michigan, USA; Rackham Arthritis Research Unit, University of Michigan, Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan, Medical Center, Ann Arbor, Michigan, USA; College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan, Medical Center, Ann Arbor, Michigan, USA; College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Upjohn Center for Clinical Pharmacology, University of Michigan, Medical Center, Ann Arbor, Michigan, USA; Farmasötik Teknoloji, Kürsüsü, Tandoğan, Ankara Üniversitesi Eczacilik Fakültesi, Ankara, Turkey | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 527636 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46638/1/228_2004_Article_BF00568200.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00568200 | en_US |
dc.identifier.source | European Journal of Clinical Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.