Genetic control of the immune response in mice: V. Minor genes involved in the response to H-Y and Ea-1 antigens
dc.contributor.author | Gasser, David L. | en_US |
dc.contributor.author | Shreffler, Donald C. | en_US |
dc.date.accessioned | 2006-09-11T18:08:02Z | |
dc.date.available | 2006-09-11T18:08:02Z | |
dc.date.issued | 1974-12 | en_US |
dc.identifier.citation | Gasser, David L.; Shreffler, Donald C.; (1974). "Genetic control of the immune response in mice: V. Minor genes involved in the response to H-Y and Ea-1 antigens." Immunogenetics 1(1): 133-140. <http://hdl.handle.net/2027.42/46729> | en_US |
dc.identifier.issn | 0093-7711 | en_US |
dc.identifier.issn | 1432-1211 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46729 | |
dc.description.abstract | Murine responses to both the male specific histocompatibility antigen H-Y and the erythrocyte alloantigen Ea-1 are regulated by genetic factors. In each case a single major gene that controls the immune response has been identified, but additional modifying factors can be demonstrated if appropriate strain combinations are studied. A single gene controlling the response to Ea-1 antigens, which segregates when strains YBR and B10.D2 are crossed, has been shown not to be an allele of the Ir-2 locus. A new phenomenon has also been observed in the control of anti-Ea-1 antibody production in that the mating of two responding strains, YBR and HTG, produces an F 1 generation of complete nonresponders. By linkage tests it was shown that the responding strain HTG possesses the nonresponder allele at the Ir- 2 locus, so there appear to be recessive genes in the background which are able to overcome the suppressive influence of this allele. | en_US |
dc.format.extent | 420722 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Allergology | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Cell Biology | en_US |
dc.title | Genetic control of the immune response in mice: V. Minor genes involved in the response to H-Y and Ea-1 antigens | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Human Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46729/1/251_2005_Article_BF01564054.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01564054 | en_US |
dc.identifier.source | Immunogenetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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