Hybrid immune response to parental liver tissue grafts
dc.contributor.author | Schultz, Jane S. | en_US |
dc.contributor.author | DeMott-Friberg, Roberta | en_US |
dc.contributor.author | Beals, Theodore F. | en_US |
dc.date.accessioned | 2006-09-11T18:08:49Z | |
dc.date.available | 2006-09-11T18:08:49Z | |
dc.date.issued | 1983-09 | en_US |
dc.identifier.citation | Schultz, Jane S.; DeMott-Friberg, Roberta; Beals, Theodore F.; (1983). "Hybrid immune response to parental liver tissue grafts." Immunogenetics 17(5): 465-473. <http://hdl.handle.net/2027.42/46740> | en_US |
dc.identifier.issn | 0093-7711 | en_US |
dc.identifier.issn | 1432-1211 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46740 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=6840817&dopt=citation | en_US |
dc.description.abstract | Parental-to-F 1 -hybrid liver tissue grafts in like-sex donor-recipient combinations survive indefinitely, although several F 1 recipients demonstrate an immunological response to the parental graft. Female F 1 recipients, particularly those carrying the H-2 b haplotype, respond vigorously to male parental liver grafts. However F 1 female responses to male parental liver tissue grafts differ substantively from the responses of parental females to syngeneic male grafts. C3H male liver grafts are rejected vigorously by F 1 females as long as the F 1 carries the H-2 b haplotype. These findings support previous reports of strong immunological responses to C3H H-Y antigen in female F 1 and C3H.SW animals, a response which is absent in C3H females. Female F 1 hybrids carrying the H-2 b haplotype do not reject grafts of B10 or B6 male liver as rapidly as do B10 or B6 parental females. This reduced F 1 response may be related to the formation of hybrid antigens and consequent alteration of the anti-H-Y response. Alternatively, cells that specifically suppress the anti-H-Y response may be present in F 1 hybrids. Factors responsible for suppression appear to be controlled by non-MHC antigens, at least in (OH x B6 or B10) F 1 hybrids. | en_US |
dc.format.extent | 563473 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Allergology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Cell Biology | en_US |
dc.title | Hybrid immune response to parental liver tissue grafts | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | VA Medical Center, Ann Arbor, Michigan; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan; 151, VA Medical Center, 2215 Fuller Road, 48105, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | VA Medical Center, Ann Arbor, Michigan; Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | VA Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 6840817 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46740/1/251_2004_Article_BF00696870.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00696870 | en_US |
dc.identifier.source | Immunogenetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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