H-2 and Background influences on tissue grafts across the H-Y barrier
dc.contributor.author | Beals, Theodore F. | en_US |
dc.contributor.author | Schultz, Jane S. | en_US |
dc.contributor.author | DeMott-Friberg, Roberta | en_US |
dc.date.accessioned | 2006-09-11T18:09:53Z | |
dc.date.available | 2006-09-11T18:09:53Z | |
dc.date.issued | 1979-12 | en_US |
dc.identifier.citation | DeMott-Friberg, Roberta; Beals, Theodore F.; Schultz, Jane S.; (1979). " H-2 and Background influences on tissue grafts across the H-Y barrier." Immunogenetics 9(1): 369-381. <http://hdl.handle.net/2027.42/46755> | en_US |
dc.identifier.issn | 1432-1211 | en_US |
dc.identifier.issn | 0093-7711 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46755 | |
dc.description.abstract | Male liver was grafted to kidney beds in syngeneic female mice. Relative influences of H-2 haplotype, genetic background or interaction of H-2 haplotype with genetic background on anti-H-Y response were evaluated using 27 inbred strains carrying eight H-2 haplotypes of independent origin and three naturally occurring recombinants. Females of H-2 b haplotype acutely rejected the male graft as is reported for other tissue graft systems. An H-2 haplotype influence was found for all haplotypes studied, with a greater variation of immunologic response revealed by histological analysis of liver grafts than is demonstrated by skin grafts. Strains carrying H-2 k , H-2 j and H-2 p haplotypes expressed the greatest range of immunological variability with responses ranging from graft proliferation to graft rejection. Strains carrying the H-2 d haplotype had the most consistent responses with little reaction to the graft. The strong immune response by SJL/J ( H-2 s ) female mice to the H-Y antigen is not typical of other H-2 s strains, but is compatible with the reported hyperresponsiveness of this strain to alloantigens. | en_US |
dc.format.extent | 1155169 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Immunology | en_US |
dc.subject.other | Allergology | en_US |
dc.title | H-2 and Background influences on tissue grafts across the H-Y barrier | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center, 48105, Ann Arbor, Michigan; Departments of Genetics and Pathology, University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center, 48105, Ann Arbor, Michigan; Departments of Genetics and Pathology, University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Veterans Administration Medical Center, 48105, Ann Arbor, Michigan; Departments of Genetics and Pathology, University of Michigan, 48109, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46755/1/251_2005_Article_BF01570432.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01570432 | en_US |
dc.identifier.source | Immunogenetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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