A possible role of d -valine and related d -amino acids in repression of enzyme and actinomycin synthesis
dc.contributor.author | Brown, Dale | en_US |
dc.contributor.author | Katz, Edward | en_US |
dc.date.accessioned | 2006-09-11T18:10:06Z | |
dc.date.available | 2006-09-11T18:10:06Z | |
dc.date.issued | 1989-01 | en_US |
dc.identifier.citation | Katz, Edward; Brown, Dale; (1989). "A possible role of d -valine and related d -amino acids in repression of enzyme and actinomycin synthesis." Applied Microbiology and Biotechnology 30(1): 67-70. <http://hdl.handle.net/2027.42/46758> | en_US |
dc.identifier.issn | 0175-7598 | en_US |
dc.identifier.issn | 1432-0614 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46758 | |
dc.description.abstract | The addition of d -valine and related d -amino acids to the production medium blocks kynurenine formamidase II and actinomycin D synthesis by Streptomyces parvulus . This effect may be due to a direct inhibition of the actinomycin synthetase-catalyzed racemization of l -valine to its peptide bound d -form during antibiotic formation. In addition, the d -amino acid(s) may influence enzyme and actinomycin synthesis through carbon and/or nitrogen catabolite regulation. The relatively slow uptake and metabolism of the d -amino acid would provide a continuous supply of catabolite(s) that repress transcription of actinomycin biosynthetic genes over a long period of time. | en_US |
dc.format.extent | 323102 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Microbiology | en_US |
dc.subject.other | Biotechnology | en_US |
dc.subject.other | Microbial Genetics and Genomics | en_US |
dc.title | A possible role of d -valine and related d -amino acids in repression of enzyme and actinomycin synthesis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology, Georgetown University Schools of Medicine and Dentistry, 3900 Reservoir Rd., 20007, Washington, D.C., N.W., USA; Department of Pediatrics, Section of Pediatric Hematology, University of Michigan, 48109-0864, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Microbiology, Georgetown University Schools of Medicine and Dentistry, 3900 Reservoir Rd., 20007, Washington, D.C., N.W., USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46758/1/253_2004_Article_BF00255998.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00255998 | en_US |
dc.identifier.source | Applied Microbiology and Biotechnology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.