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Application of affinity adsorption in thienamycin fermentation
dc.contributor.authorWang, Henry Y.en_US
dc.contributor.authorPalanki, Srinivasen_US
dc.contributor.authorHyatt, Gregory S.en_US
dc.date.accessioned2006-09-11T18:10:10Z
dc.date.available2006-09-11T18:10:10Z
dc.date.issued1989-02en_US
dc.identifier.citationWang, Henry Y.; Palanki, Srinivas; Hyatt, Gregory S.; (1989). "Application of affinity adsorption in thienamycin fermentation." Applied Microbiology and Biotechnology 30(2): 115-119. <http://hdl.handle.net/2027.42/46759>en_US
dc.identifier.issn0175-7598en_US
dc.identifier.issn1432-0614en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46759
dc.description.abstractMany antibiotic fermentations are sensitive to high concentrations of their own product possibly due to product regulation and toxicity mechanisms. In this paper we discuss the feasibility of using affinity adsorption with biospecific ligands for in situ product removal to alleviate this problem. The concept of using whole cells containing the biospecific ligands is demonstrated in the case of thienamycin fermentation using whole cells of Bacillus stearothermophilus and immobilized β-lactamase. It is observed that thienamycin production continues for an extended period of time.en_US
dc.format.extent446046 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherChemistryen_US
dc.subject.otherMicrobiologyen_US
dc.subject.otherBiotechnologyen_US
dc.subject.otherMicrobial Genetics and Genomicsen_US
dc.titleApplication of affinity adsorption in thienamycin fermentationen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Chemical Engineering, The University of Michigan, 48109, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46759/1/253_2004_Article_BF00263996.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00263996en_US
dc.identifier.sourceApplied Microbiology and Biotechnologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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