Scintigraphy of incidentally discovered bilateral adrenal masses
dc.contributor.author | Gross, Milton D. | en_US |
dc.contributor.author | Korobkin, Melvyn T. | en_US |
dc.contributor.author | Shapiro, Brahm | en_US |
dc.contributor.author | Francise, Isaac R. | en_US |
dc.contributor.author | Bree, Robert L. | en_US |
dc.contributor.author | McLeod, Michael K. | en_US |
dc.contributor.author | Thompson, Norman W. | en_US |
dc.contributor.author | Sanfield, Jeffrey A. | en_US |
dc.date.accessioned | 2006-09-11T18:15:54Z | |
dc.date.available | 2006-09-11T18:15:54Z | |
dc.date.issued | 1995-04 | en_US |
dc.identifier.citation | Gross, Milton D.; Shapiro, Brahm; Francise, Isaac R.; Bree, Robert L.; Korobkin, Melvyn; McLeod, Michael K.; Thompson, Norman W.; Sanfield, Jeffrey A.; (1995). "Scintigraphy of incidentally discovered bilateral adrenal masses." European Journal of Nuclear Medicine 22(4): 315-321. <http://hdl.handle.net/2027.42/46838> | en_US |
dc.identifier.issn | 0340-6997 | en_US |
dc.identifier.issn | 1619-7089 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46838 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7607261&dopt=citation | en_US |
dc.description.abstract | The purpose of this study was to determine the patterns of iodine-131 6β-iodomethylnorcholesterol (NP-59) imaging and the correlation with computed tomography (CT)-guided adrenal biopsy and follow-up in patients with bilateral adrenal masses. To this end we investigated a consecutive sample of 29 euadrenal patients with bilateral adrenal masses discovered on CT for reasons other than suspected adrenal disease. Adrenal scintigraphy was performed using 1 mCi of NP-59 injected intravenously, with gamma camera imaging 5–7 days later. In 13 of the 29 patients bilateral adrenal masses were the result of metastatic involvement from lung carcinoma (5), lymphoma (3), adrenocarcinoma of the colon (3), squamous cell carcinoma of the larynx (1), and anaplastic carcinoma of unknown primary (1). Among these cases the NP-59 scan demonstrated either bilaterally absent tracer accumulation (in eight, all with bilateral metastases proven by CT guided biopsy or progression on follow-up CT) or marked asymmetry of adrenocortical NP-59 uptake (in five). Biopsy of the adrenal demonstrating the least NP-59 uptake documented malignant involvement of that gland in five of five patients. In two patients an adenoma was found simultaneously in one adrenal with a contralateral malignant adrenal mass. In each of these cases, the adenoma demonstrated the greatest NP-59 uptake. In 16 patients diagnosis of adenoma was made on the basis of (a) CT guided adrenal biopsy of the gland with the greatest NP-59 uptake of the pair ( n =4), or (b) adrenalectomy ( n =2), or (c) absence of change in the size of the adrenal mass on follow-up CT scanning performed 6 months to 3 years later ( n =10). It is concluded that differential in vivo functional information provided by NP-59 scintigraphy complements that derived from anatomic imaging and can be used in patients with bilateral adrenal masses to select which gland would be the best choice for further diagnostic invasive evaluation (e.g., adrenal biopsy) or may suggest the presence of bilateral adrenal metastases in patients with incidentally discovered, bilateral adrenal masses. | en_US |
dc.format.extent | 1267258 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Nuclear Medicine | en_US |
dc.subject.other | Iodine-131 6β-Iodomethylnorcholesterol | en_US |
dc.subject.other | Imaging / Radiology | en_US |
dc.subject.other | Adrenal | en_US |
dc.subject.other | Neoplasm | en_US |
dc.title | Scintigraphy of incidentally discovered bilateral adrenal masses | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, The University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine (Division of Nuclear Medicine), The University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA; Dept. of Veterans Affairs Medical Center, Nuclear Medicine Service (115), 2215 Fuller Road, 48105, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine (Division of Nuclear Medicine), The University of Michigan and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | The Catherine McAuley Health Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7607261 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46838/1/259_2004_Article_BF00941847.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00941847 | en_US |
dc.identifier.source | European Journal of Nuclear Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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