The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine
dc.contributor.author | Ostruszka, Leo J. | en_US |
dc.contributor.author | Shewach, Donna S. | en_US |
dc.date.accessioned | 2006-09-11T18:23:23Z | |
dc.date.available | 2006-09-11T18:23:23Z | |
dc.date.issued | 2003-10 | en_US |
dc.identifier.citation | Ostruszka, Leo J.; Shewach, Donna S.; (2003). "The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine." Cancer Chemotherapy and Pharmacology 52(4): 325-332. <http://hdl.handle.net/2027.42/46929> | en_US |
dc.identifier.issn | 1432-0843 | en_US |
dc.identifier.issn | 0344-5704 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46929 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12811514&dopt=citation | en_US |
dc.description.abstract | Cytotoxicity from the anticancer drug 2′,2′-difluoro-2′-deoxycytidine (dFdCyd) has been correlated with its incorporation into DNA. However, cytotoxicity may also result from inhibition of DNA synthesis, due to either (1) dFdCyd diphosphate-mediated inhibition of ribonucleotide reductase, or (2) direct inhibition of DNA polymerases by the 5′-triphosphate of dFdCyd (dFdCTP). To elucidate the role of DNA synthesis inhibition in the cytotoxicity of dFdCyd, we compared dFdCyd to hydroxyurea (HU), a ribonucleotide reductase inhibitor, and aphidicolin, an inhibitor of DNA polymerases, in the U251 and D54 human glioblastoma cell lines. | en_US |
dc.format.extent | 298669 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | DNTP | en_US |
dc.subject.other | DFdCyd | en_US |
dc.subject.other | DNA Synthesis | en_US |
dc.subject.other | Medicine | en_US |
dc.subject.other | Ribonucleotide Reductase | en_US |
dc.title | The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, 1310 E. Catherine St., Ann Arbor, MI 48109-0504, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, 1310 E. Catherine St., Ann Arbor, MI 48109-0504, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12811514 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46929/1/280_2003_Article_661.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00280-003-0661-5 | en_US |
dc.identifier.source | Cancer Chemotherapy and Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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