A self-renewal assay for cancer stem cells
dc.contributor.author | Clarke, Michael F. | en_US |
dc.date.accessioned | 2006-09-11T18:23:35Z | |
dc.date.available | 2006-09-11T18:23:35Z | |
dc.date.issued | 2005-11 | en_US |
dc.identifier.citation | Clarke, Michael F.; (2005). "A self-renewal assay for cancer stem cells." Cancer Chemotherapy and Pharmacology 56(7): 64-68. <http://hdl.handle.net/2027.42/46932> | en_US |
dc.identifier.issn | 1432-0843 | en_US |
dc.identifier.issn | 0344-5704 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46932 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16273355&dopt=citation | en_US |
dc.description.abstract | Cancers of epithelial origin are responsible for the majority of cancer-related deaths in the USA. Unfortunately, although chemotherapy and/or radiation therapy can sometimes shrink tumors, metastatic cancers of epithelial origin are essentially incurable. It is clear that new approaches are needed to treat these diseases. Although cancer cell lines provide invaluable information, their biological properties often differ in crucial ways from de novo cancer cells. Our laboratory has developed a novel mouse model that reliably permits individual cancer cells isolated directly from patients’ tumors to be assayed. This will allow the characterization of crucial signaling pathways involved in processes such as self-renewal that are critical for tumor formation by the cancer cells within de novo tumors. These tools should lead to new insights into the cellular and molecular mechanisms that drive human breast cancer growth and invasion. | en_US |
dc.format.extent | 312134 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Self-renewal | en_US |
dc.subject.other | Cancer | en_US |
dc.subject.other | Stem Cells | en_US |
dc.title | A self-renewal assay for cancer stem cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, 1500 East Medical Center Drive, CCGC 4303, Ann Arbor, MI, 48109, USA, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16273355 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46932/1/280_2005_Article_97.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00280-005-0097-1 | en_US |
dc.identifier.source | Cancer Chemotherapy and Pharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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