Hydrophilic polymers containing chiral nucleic acid base pendants as polynucleotide analogs
dc.contributor.author | Kikyotani, S. | en_US |
dc.contributor.author | Ludwick, Adriane G. | en_US |
dc.contributor.author | Brandt, K. A. | en_US |
dc.contributor.author | Overberger, Charles Gilbert | en_US |
dc.date.accessioned | 2006-09-11T18:25:07Z | |
dc.date.available | 2006-09-11T18:25:07Z | |
dc.date.issued | 1981-11 | en_US |
dc.identifier.citation | Overberger, C. G.; Brandt, K. A.; Kikyotani, S.; Ludwick, Adriane G.; (1981). "Hydrophilic polymers containing chiral nucleic acid base pendants as polynucleotide analogs." Polymer Bulletin 5 (9-10): 481-488. <http://hdl.handle.net/2027.42/46953> | en_US |
dc.identifier.issn | 1436-2449 | en_US |
dc.identifier.issn | 0170-0839 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46953 | |
dc.description.abstract | A survey of our recent work on synthetic polynucleotide analogs is given. Propionic acid and 3-methyl butyric acid derivatives substituted in the 2-position with nucleic acid bases have been used as chiral pendants for attachment to hydrophilic polyamine backbones. Hindered rotation about the amide bonds formed promotes a base-stacked structure as shown by ultraviolet hypochromic effects versus model compounds. If the pendant has been resolved, an optically active polymer results which may be studied by circular dichroism (CD). Thus, poly(ethylenimine) containing the (−)-2-(thymin-1-yl)-propionyl group as the grafted pendant showed exciton coupling of the B 2u transition of the base chromophores in the CD, as observed in polynucleotides. This implies at least a local helical order in the stacking. The biological activity of such structures is briefly discussed. | en_US |
dc.format.extent | 323881 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Polymer Sciences | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Materials Processing, Characterization, and Design | en_US |
dc.subject.other | Condensed Matter and Material Sciences | en_US |
dc.subject.other | Industrial Chemistry/Chemical Engineering | en_US |
dc.title | Hydrophilic polymers containing chiral nucleic acid base pendants as polynucleotide analogs | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry and the Macromolecular Research Center, The University of Michigan, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Chemistry and the Macromolecular Research Center, The University of Michigan, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Chemistry and the Macromolecular Research Center, The University of Michigan, 48109, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Chemistry and the Macromolecular Research Center, The University of Michigan, 48109, Ann Arbor, MI, USA; Department of Chemistry, Tuskegee Institute, 36088, Tuskegee, Alabama, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46953/1/289_2004_Article_BF00254354.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00254354 | en_US |
dc.identifier.source | Polymer Bulletin | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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