Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene
dc.contributor.author | Guan, Kun-Liang | en_US |
dc.contributor.author | Farh, Lynn | en_US |
dc.contributor.author | Marshall, Tricia K. | en_US |
dc.contributor.author | Deschenes, Robert J. | en_US |
dc.date.accessioned | 2006-09-11T18:26:48Z | |
dc.date.available | 2006-09-11T18:26:48Z | |
dc.date.issued | 1993-07 | en_US |
dc.identifier.citation | Guan, Kunliang; Farh, Lynn; Marshall, Tricia K.; Deschenes, Robert J.; (1993). "Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene." Current Genetics 24 (1-2): 141-148. <http://hdl.handle.net/2027.42/46976> | en_US |
dc.identifier.issn | 1432-0983 | en_US |
dc.identifier.issn | 0172-8083 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46976 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7916673&dopt=citation | en_US |
dc.description.abstract | The isolation and characterization of MGM1 , and yeast gene with homology to members of the dynamin gene family, is described. The MGM1 gene is located on the right arm of chromosome XV between STE4 and PTP2 . Sequence analysis revealed a single open reading frame of 902 residues capable of encoding a protein with an approximate molecular mass of 101 kDa. Loss of MGM1 resulted in slow growth on rich medium, failure to grow on non-fermentable carbon sources, and loss of mitochondrial DNA. The mitochondria also appeared abnormal when visualized with an antibody to a mitochondrial-matrix marker. MGM1 encodes a dynamin-like protein involved in the propagation of functional mitochondria in yeast. | en_US |
dc.format.extent | 1419263 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Mitochondria | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Saccharomyces Cerevisiae | en_US |
dc.subject.other | Microbial Genetics and Genomics | en_US |
dc.subject.other | Plant Sciences | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Proteomics | en_US |
dc.subject.other | Microbiology | en_US |
dc.subject.other | Dynamin | en_US |
dc.subject.other | GTP Binding Protein | en_US |
dc.title | Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biochemistry, University of Michigan, 48109-0606, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry, University of Iowa, 52242, Iowa City, IA, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry, University of Iowa, 52242, Iowa City, IA, USA | en_US |
dc.contributor.affiliationother | Department of Biochemistry, University of Iowa, 52242, Iowa City, IA, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7916673 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46976/1/294_2004_Article_BF00324678.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00324678 | en_US |
dc.identifier.source | Current Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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