Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus
dc.contributor.author | Sandstedt, Sara A. | en_US |
dc.contributor.author | Tucker, Priscilla K. | en_US |
dc.date.accessioned | 2006-09-11T18:27:37Z | |
dc.date.available | 2006-09-11T18:27:37Z | |
dc.date.issued | 2006-01 | en_US |
dc.identifier.citation | Sandstedt, Sara A.; Tucker, Priscilla K.; (2006). "Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus ." Mammalian Genome 17(1): 14-21. <http://hdl.handle.net/2027.42/46987> | en_US |
dc.identifier.issn | 0938-8990 | en_US |
dc.identifier.issn | 1432-1777 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/46987 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16416087&dopt=citation | en_US |
dc.description.abstract | Two related genes with potentially similar functions, one on the Y chromosome and one on the X chromosome, were examined to determine if they evolved differently because of their chromosomal positions. Six hundred fifty-seven base pairs of coding sequence of Jarid1d ( Smcy ) on the Y chromosome and Jarid1c ( Smcx ) on the X chromosome were sequenced in 13 rodent taxa. An analysis of replacement and silent substitutions, using a counting method designed for samples with small evolutionary distances, showed a significant difference between the two genes. The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties. These findings are similar to results of previous studies of Y chromosomal genes in these and other mammalian taxa, suggesting that genes on the mammalian Y evolve in a chromosome-specific manner. | en_US |
dc.format.extent | 132977 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer Science+Business Media, Inc. | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Zoology | en_US |
dc.subject.other | Anatomy | en_US |
dc.subject.other | Cell Biology | en_US |
dc.title | Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Ecology and Evolutionary Biology, and Museum of Zoology, University of Michigan, Ann Arbor, Michigan, 48109, USA | en_US |
dc.contributor.affiliationum | Department of Ecology and Evolutionary Biology, and Museum of Zoology, University of Michigan, Ann Arbor, Michigan, 48109, USA; Department of Epidemiology, University of Michigan, 109 Observatory, Rm 2010 School of Public Health Building I, Ann Arbor, MI, 48109, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16416087 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/46987/1/335_2005_Article_50.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00335-005-0050-y | en_US |
dc.identifier.source | Mammalian Genome | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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