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Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus

dc.contributor.authorSandstedt, Sara A.en_US
dc.contributor.authorTucker, Priscilla K.en_US
dc.date.accessioned2006-09-11T18:27:37Z
dc.date.available2006-09-11T18:27:37Z
dc.date.issued2006-01en_US
dc.identifier.citationSandstedt, Sara A.; Tucker, Priscilla K.; (2006). "Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus ." Mammalian Genome 17(1): 14-21. <http://hdl.handle.net/2027.42/46987>en_US
dc.identifier.issn0938-8990en_US
dc.identifier.issn1432-1777en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/46987
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16416087&dopt=citationen_US
dc.description.abstractTwo related genes with potentially similar functions, one on the Y chromosome and one on the X chromosome, were examined to determine if they evolved differently because of their chromosomal positions. Six hundred fifty-seven base pairs of coding sequence of Jarid1d ( Smcy ) on the Y chromosome and Jarid1c ( Smcx ) on the X chromosome were sequenced in 13 rodent taxa. An analysis of replacement and silent substitutions, using a counting method designed for samples with small evolutionary distances, showed a significant difference between the two genes. The different patterns of replacement and silent substitutions within Jarid1d and Jarid1c may be a result of evolutionary mechanisms that are particularly strong on the Y chromosome because of its unique properties. These findings are similar to results of previous studies of Y chromosomal genes in these and other mammalian taxa, suggesting that genes on the mammalian Y evolve in a chromosome-specific manner.en_US
dc.format.extent132977 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer Science+Business Media, Inc.en_US
dc.subject.otherLife Sciencesen_US
dc.subject.otherZoologyen_US
dc.subject.otherAnatomyen_US
dc.subject.otherCell Biologyen_US
dc.titleInefficient purifying selection: the mammalian Y chromosome in the rodent genus Musen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Ecology and Evolutionary Biology, and Museum of Zoology, University of Michigan, Ann Arbor, Michigan, 48109, USAen_US
dc.contributor.affiliationumDepartment of Ecology and Evolutionary Biology, and Museum of Zoology, University of Michigan, Ann Arbor, Michigan, 48109, USA; Department of Epidemiology, University of Michigan, 109 Observatory, Rm 2010 School of Public Health Building I, Ann Arbor, MI, 48109, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid16416087en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/46987/1/335_2005_Article_50.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00335-005-0050-yen_US
dc.identifier.sourceMammalian Genomeen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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