Molecular map of Chromosome 19 including three genes affecting bleeding time: ep, ru , and bm

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dc.contributor.author Novak, E. K. en_US
dc.contributor.author Keller, Scot A. en_US
dc.contributor.author O'Brien, E. P. en_US
dc.contributor.author Guénet, J. -L. en_US
dc.contributor.author Poirier, C. en_US
dc.contributor.author Swank, Richard T. en_US
dc.date.accessioned 2006-09-11T18:29:19Z
dc.date.available 2006-09-11T18:29:19Z
dc.date.issued 1994-06 en_US
dc.identifier.citation O'Brien, E. P.; Novak, E. K.; Keller, S. A.; Poirier, C.; Guénet, J.-L.; Swank, R. T.; (1994). "Molecular map of Chromosome 19 including three genes affecting bleeding time: ep, ru , and bm ." Mammalian Genome 5(6): 356-360. <http://hdl.handle.net/2027.42/47011> en_US
dc.identifier.issn 0938-8990 en_US
dc.identifier.issn 1432-1777 en_US
dc.identifier.uri http://hdl.handle.net/2027.42/47011
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8043950&dopt=citation en_US
dc.description.abstract The mouse ruby eye ( ru ) and pale ear ( ep ) pigment dilution genes cause platelet storage pool deficiency (SPD) and prolonged bleeding times. The brachymorphic ( bm ) gene, in addition to causing skeletal abnormalities, is also associated with prolonged bleeding times. All three hemorrhagic genes are found within 10 cM on Chromosome (Chr) 19. In this study, 15 microsatellite markers and five cDNAs, spanning 21 cM of Chr 19, were mapped in relation to the bm, ep , and ru genes in 457 progeny of an interspecific backcross utilizing the highly inbred strain PWK derived from the Mus musculus musculus species. Several markers were found to be closely linked to the three genes and should be useful as entry points in their eventual molecular identification. en_US
dc.format.extent 597655 bytes
dc.format.extent 3115 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language.iso en_US
dc.publisher Springer-Verlag en_US
dc.subject.other Cell Biology en_US
dc.subject.other Life Sciences en_US
dc.subject.other Anatomy en_US
dc.subject.other Zoology en_US
dc.title Molecular map of Chromosome 19 including three genes affecting bleeding time: ep, ru , and bm en_US
dc.type Original Contributions en_US
dc.subject.hlbsecondlevel Natural Resources and Environment en_US
dc.subject.hlbsecondlevel Molecular, Cellular and Developmental Biology en_US
dc.subject.hlbsecondlevel Ecology and Evolutionary Biology en_US
dc.subject.hlbtoplevel Health Sciences en_US
dc.subject.hlbtoplevel Science en_US
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Human Genetics, University of Michigan, 48109, Ann Arbor, Michigan, USA en_US
dc.contributor.affiliationother Unité de Génétique des Mammiféres, Institut Pasteur de Paris, 75724, Paris Cedex 15, France en_US
dc.contributor.affiliationother Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Carlton and Elm Streets, 14263, Buffalo, New York, USA en_US
dc.contributor.affiliationother Unité de Génétique des Mammiféres, Institut Pasteur de Paris, 75724, Paris Cedex 15, France en_US
dc.contributor.affiliationother Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Carlton and Elm Streets, 14263, Buffalo, New York, USA en_US
dc.contributor.affiliationother Molecular and Cellular Biology Department, Roswell Park Cancer Institute, Carlton and Elm Streets, 14263, Buffalo, New York, USA en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 8043950 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/47011/1/335_2004_Article_BF00356554.pdf en_US
dc.identifier.doi http://dx.doi.org/10.1007/BF00356554 en_US
dc.identifier.source Mammalian Genome en_US
dc.owningcollname Interdisciplinary and Peer-Reviewed
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