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Localization of the murine cholecystokinin A and B receptor genes
dc.contributor.authorIsakoff, M. S.en_US
dc.contributor.authorLacourse, K. A.en_US
dc.contributor.authorSamuelson, Linda C.en_US
dc.date.accessioned2006-09-11T18:30:00Z
dc.date.available2006-09-11T18:30:00Z
dc.date.issued1995-04en_US
dc.identifier.citationSamuelson, L. C.; Isakoff, M. S.; Lacourse, K. A.; (1995). "Localization of the murine cholecystokinin A and B receptor genes." Mammalian Genome 6(4): 242-246. <http://hdl.handle.net/2027.42/47021>en_US
dc.identifier.issn1432-1777en_US
dc.identifier.issn0938-8990en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/47021
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7613026&dopt=citationen_US
dc.description.abstractWe have determined the chromosomal locations of the two cholecystokinin (CCK) receptor genes in the mouse. Genetic localization utilized an interspecific backcross panel formed from the cross (C57BL/6J x Mus spretus ) F 1 x Mus spretus . Genomic DNAs from 94 individuals in the backcross were analyzed by Southern hybridization with rat CCK A and CCK B receptor cDNA probes. Unique map positions were determined by haplotype analysis with 650 previously mapped loci in the mouse backcross. The CCK A receptor gene ( Cckar ) mapped to mouse Chromosome (Chr) 5, in tight linkage with the DNA marker D5Bir8 . The CCK B receptor gene ( Cckbr ) mapped to mouse Chr 7, tightly linked to the β-hemoglobin locus ( Hbb ). This localization places Cckbr in the same region as the mouse obesity mutation tubby ( tub ), which also maps near Hbb (2.4±1.4 cM). Since CCK can function as a satiety factor when administered to rodents, localization of Cckbr near the tub mutation identifies this receptor as a possible candidate gene for this obesity mutation.en_US
dc.format.extent706907 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlagen_US
dc.subject.otherLife Sciencesen_US
dc.subject.otherZoologyen_US
dc.subject.otherCell Biologyen_US
dc.subject.otherAnatomyen_US
dc.titleLocalization of the murine cholecystokinin A and B receptor genesen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, 7761 Medical Science II, 48109-0622, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, 7761 Medical Science II, 48109-0622, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan, 7761 Medical Science II, 48109-0622, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid7613026en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/47021/1/335_2004_Article_BF00352408.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/BF00352408en_US
dc.identifier.sourceMammalian Genomeen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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