Homologs of genes and anonymous loci on human Chromosome 13 map to mouse Chromosomes 8 and 14
dc.contributor.author | Hendel, E. | en_US |
dc.contributor.author | Tchetgen, M. -B. N. | en_US |
dc.contributor.author | Koizumi, T. | en_US |
dc.contributor.author | Nadeau, J. H. | en_US |
dc.contributor.author | Lalley, P. A. | en_US |
dc.date.accessioned | 2006-09-11T18:30:04Z | |
dc.date.available | 2006-09-11T18:30:04Z | |
dc.date.issued | 1995-04 | en_US |
dc.identifier.citation | Koizumi, T.; Hendel, E.; Lalley, P. A.; Tchetgen, M. -B. N.; Nadeau, J. H.; (1995). "Homologs of genes and anonymous loci on human Chromosome 13 map to mouse Chromosomes 8 and 14." Mammalian Genome 6(4): 263-268. <http://hdl.handle.net/2027.42/47022> | en_US |
dc.identifier.issn | 0938-8990 | en_US |
dc.identifier.issn | 1432-1777 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47022 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7613031&dopt=citation | en_US |
dc.description.abstract | To enhance the comparative map for human Chromosome (Chr) 13, we identified clones for human genes and anonymous loci that cross-hybridized with their mouse homologs and then used linkage crosses for mapping. Of the clones for four genes and twelve anonymous loci tested, cross-hybridization was found for six, COL4A1, COL4A2, D13S26, D13S35, F10, and PCCA. Strong evidence for homology was found for COL4A1, COL4A2, D13S26, D13S35, and F10, but only circumstantial homology evidence was obtained for PCCA. To genetically map these mouse homologs ( Cf10, Col4a1, Col4a2, D14H13S26, D8H13S35 , and Pcca-rs ), we used interspecific and intersubspecific mapping panels. D14H13S26 and Pcca-rs were located on the distal portion of mouse Chr 14 extending by ∼30 cM the conserved linkage between human Chr 13 and mouse Chr 14, assuming that Pcca-rs is the mouse homolog of PCCA. By contrast, Cf10, Col4a1, Col4a2 , and D8H13S35 mapped near the centromere of mouse Chr 8, defining a new conserved linkage. Finally, we identified either a closely linked sequence related to Col4a2 , or a recombination hot-spot between Col4a1 and Col4a2 that has been conserved in humans and mice. | en_US |
dc.format.extent | 852572 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Cell Biology | en_US |
dc.subject.other | Zoology | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Anatomy | en_US |
dc.title | Homologs of genes and anonymous loci on human Chromosome 13 map to mouse Chromosomes 8 and 14 | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Jackson Laboratory, 04609, Bar Harbor, Maine, USA; Department of Urology, University of Michigan, 48109, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Laboratory Animal Center, Fukui Medical School, 910-11, Matsuoka, Fukui, Japan | en_US |
dc.contributor.affiliationother | The Jackson Laboratory, 04609, Bar Harbor, Maine, USA | en_US |
dc.contributor.affiliationother | Center for Molecular Biology, Wayne State University, 48202, Detroit, Michigan, USA | en_US |
dc.contributor.affiliationother | The Jackson Laboratory, 04609, Bar Harbor, Maine, USA; Department of Human Genetics and Department of Medicine, Montreal General Hospital, 1650 Cedar Avenue, H3G 1A4, Montreal, Quebec, Canada | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7613031 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47022/1/335_2004_Article_BF00352413.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF00352413 | en_US |
dc.identifier.source | Mammalian Genome | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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