Effect of dietary fat on early morphological intestinal adaptation in a rat with short bowel syndrome
dc.contributor.author | Drongowski, Robert A. | en_US |
dc.contributor.author | Mor-Vaknin, Nirit | en_US |
dc.contributor.author | Miselevich, Iness | en_US |
dc.contributor.author | Coran, Arnold G. | en_US |
dc.contributor.author | Harmon, Carroll M. | en_US |
dc.date.accessioned | 2006-09-11T18:39:46Z | |
dc.date.available | 2006-09-11T18:39:46Z | |
dc.date.issued | 2004-06 | en_US |
dc.identifier.citation | Mor-Vaknin, Nirit; Drongowski, Robert A.; Miselevich, Ines; Coran, Arnold G.; Harmon, Carroll M.; (2004). "Effect of dietary fat on early morphological intestinal adaptation in a rat with short bowel syndrome." Pediatric Surgery International 20(6): 419-424. <http://hdl.handle.net/2027.42/47163> | en_US |
dc.identifier.issn | 1437-9813 | en_US |
dc.identifier.issn | 0179-0358 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/47163 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=15108013&dopt=citation | en_US |
dc.description.abstract | Among factors promoting mucosal hyperplasia after bowel resection, long-chain fatty acids may have a special role. The purpose of the present study was to evaluate the effects of high-fat diet (HFD) on early intestinal adaptation in rats with short bowel syndrome (SBS). Male Sprague-Dawley rats underwent either a bowel transection with re-anastomosis (Sham rats) or 75% small bowel resection (SBS rats). Animals were randomly assigned to one of three groups: Sham rats fed normal chow (Sham-NC); SBS rats fed NC (SBS-NC); and SBS rats fed HFD (SBS-HFD). Rats were killed on days 3 or 14. Body weight and parameters of intestinal adaptation (overall bowel and mucosal weight, mucosal DNA and protein, villus height, and crypt depth) were determined at time of killing. By day 3, SBS-HFD rats demonstrated higher duodenal and jejunal bowel and mucosal weights and ileal villus height and jejunal crypt depth vs SBS-NC rats. By day 14 SBS-HFD rats continued to demonstrate increased duodenal and jejunal bowel weight and duodenal mucosal weight vs SBS-NC animals. We conclude that early exposure to HFD both augmented and accelerated structural bowel adaptation in a rat model of SBS. | en_US |
dc.format.extent | 326181 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Short Bowel Syndrome | en_US |
dc.subject.other | Diet | en_US |
dc.subject.other | Intestinal Adaptation | en_US |
dc.subject.other | Lipid | en_US |
dc.subject.other | Medicine | en_US |
dc.title | Effect of dietary fat on early morphological intestinal adaptation in a rat with short bowel syndrome | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C.S. Mott Children’s Hospital and University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C.S. Mott Children’s Hospital and University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C.S. Mott Children’s Hospital and University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Section of Pediatric Surgery, C.S. Mott Children’s Hospital and University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Rappaport Faculty of Medicine, Technion, Bnai Zion Medical Center, Haifa, Israel | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 15108013 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/47163/1/383_2004_Article_1168.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00383-004-1168-9 | en_US |
dc.identifier.source | Pediatric Surgery International | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.